DegronMD

Uniprot ID: Q969F2

Source protein: Protein naked cuticle homolog 2

Source gene: NKD2

Class: DEG_SCF_FBW7_2

Location: 414:421

E3 ligase: FBXW7

DEGRON score: 0.9942

ASA_SCORE: 64.5375

COIL: 0.9006

CONS_SCORE: 0.3403

DSS_SCORE: 0.6289

HELIX: 0.0373

FCONS_SCORE: 0.8187

RIG_SCORE: 0.6172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H408Y	TCGA-CK-4951	COAD	TCGA	LPPTPAGE	DEG_SCF_FBW7_2	0.1667
p.T417M	DO50451	ESAD	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	0.7423
p.T417M	DO233920	GACA	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	0.7423
p.T417M	SIDM01265	Plasma Cell Myeloma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.7423
p.T417M	SIDM01126	Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.7423
p.T417M	SIDM00721	Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.7423
p.T417M	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.7423
p.R430Q	DO234357	ESAD	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	0.0833
p.A424V	DO233899	GACA	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	0.25
p.P415L	DO228176	PBCA	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM00267	Biliary Tract Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM00296	Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM00589	Oral Cavity Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM00301	Pancreatic Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM00687	Gastric Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM01735	Biliary Tract Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.P415L	SIDM01494	Glioblastoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.6471
p.R412Q	SIDM01293	Colorectal Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.2778
p.R430W	SIDM00631	Breast Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969F2	Protein naked cuticle homolog 2	DEG_SCF_FBW7_2	414:421	LPPTPAGE	FBXW7	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons