DegronMD - Q9UPW8(UNC13A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R229C	TCGA-06-5416	GBM	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.719
p.R229C	DO10880	GBM	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.719
p.G234S	TCGA-21-1071	LUSC	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.G234S	DO26918	LUSC	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.P210S	TCGA-21-1079	LUSC	TCGA	PPPY	ITCH	210:213	Mutation altering degron motif	0.6752
p.P210S	TCGA-90-A4ED	LUSC	TCGA	PPPY	ITCH	210:213	Mutation altering degron motif	0.6752
p.P210S	DO26846	LUSC	ICGC	PPPY	ITCH	210:213	Mutation altering degron motif	0.6752
p.P210S	DO45482	LUSC	ICGC	PPPY	ITCH	210:213	Mutation altering degron motif	0.6752
p.P210S	DO222516	MELA	ICGC	PPPY	ITCH	210:213	Mutation altering degron motif	0.6752
p.T216M	TCGA-30-1718	OV	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.T216M	TCGA-30-1718	OV	TCGA	PPPY	ITCH	210:213	Mutation rewiring degron network	0.25
p.T216M	TCGA-AO-A0J6	BRCA	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.T216M	TCGA-AO-A0J6	BRCA	TCGA	PPPY	ITCH	210:213	Mutation rewiring degron network	0.25
p.T216M	DO4233	BRCA	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.T216M	DO4233	BRCA	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.25
p.T216M	DO45185	LIRI	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.T216M	DO45185	LIRI	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.25
p.T216M	DO32708	OV	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.T216M	DO32708	OV	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.25
p.T216M	SIDM01619	Endometrial Carcinoma	GDSC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.T216M	SIDM01619	Endometrial Carcinoma	GDSC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.25
p.T216M	ACH-000984	Endometrial/Uterine Cancer	CCLE	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.T216M	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	210:213	Mutation rewiring degron network	0.25
p.Y239H	TCGA-86-8585	LUAD	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.0833
p.Y239H	DO24850	LUAD	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.0833
p.T215S	TCGA-AD-6964	COAD	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.1944
p.T215S	TCGA-AD-6964	COAD	TCGA	PPPY	ITCH	210:213	Mutation rewiring degron network	0.2778
p.T215S	DO8360	COAD	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.1944
p.T215S	DO8360	COAD	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.2778
p.T205M	TCGA-B5-A3FC	UCEC	TCGA	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	DO33768	PACA	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	DO41871	UCEC	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	DO43755	UCEC	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	SIDM02011	Pancreatic Carcinoma	GDSC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	SIDM00043	Head and Neck Carcinoma	GDSC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	ACH-002297	Head and Neck Cancer	CCLE	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.T205M	PCI-4B	upper aerodigestive tract	COSMIC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.1944
p.R229H	TCGA-DX-A1L2	SARC	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.7133
p.R229H	TCGA-F1-6177	STAD	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.7133
p.R229H	DO219951	SARC	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.7133
p.R229H	DO38727	STAD	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.7133
p.P210T	TCGA-FS-A1ZB	SKCM	TCGA	PPPY	ITCH	210:213	Mutation altering degron motif	0.7031
p.P210T	DO37886	SKCM	ICGC	PPPY	ITCH	210:213	Mutation altering degron motif	0.7031
p.L233M	TCGA-FS-A1ZZ	SKCM	TCGA	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.25
p.L233M	DO37412	SKCM	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.25
p.P210Q	TCGA-G7-6795	KIRP	TCGA	PPPY	ITCH	210:213	Mutation altering degron motif	0.7035
p.P210Q	DO20851	KIRP	ICGC	PPPY	ITCH	210:213	Mutation altering degron motif	0.7035
p.S208R	DO233105	GACA	ICGC	PPPY	ITCH	210:213	Mutation rewiring degron network	0.2778
p.S235A	DO45049	LINC	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.1944
p.G234D	DO220903	MELA	ICGC	NASVHQYSVRP	CBL_PTK	220:230	Mutation rewiring degron network	0.2222
p.A221D	SIDM00334	Endometrial Carcinoma	GDSC	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.6682
p.A221D	ACH-000879	Endometrial/Uterine Cancer	CCLE	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.6682
p.A221D	MFE-296	endometrium	COSMIC	NASVHQYSVRP	CBL_PTK	220:230	Mutation altering degron motif	0.6682

Kaplan plot for UNC13A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC13A

UniProt ID: Q9UPW8

Entrez ID: 23025

Protein name: Protein unc-13 homolog A (Munc13-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNC13A in