DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NASVHQYSVRP
Uniprot ID:
Q9UPW8
Source protein:
Protein unc-13 homolog A
Source gene:
UNC13A
Class:
CBL_PTK
Location:
220:230
E3 ligase:
CBL
DEGRON score:
0.8741
ASA_SCORE:
91.9
COIL:
0.8605
CONS_SCORE:
0.4188
DSS_SCORE:
0.6343
HELIX:
0.1028
FCONS_SCORE:
1.0275
RIG_SCORE:
0.6634
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R229C
TCGA-06-5416
GBM
TCGA
NASVHQYSVRP
CBL_PTK
0.719
p.R229C
DO10880
GBM
ICGC
NASVHQYSVRP
CBL_PTK
0.719
p.G234S
TCGA-21-1071
LUSC
TCGA
NASVHQYSVRP
CBL_PTK
0.2222
p.G234S
DO26918
LUSC
ICGC
NASVHQYSVRP
CBL_PTK
0.2222
p.T216M
TCGA-30-1718
OV
TCGA
NASVHQYSVRP
CBL_PTK
0.2222
p.T216M
TCGA-AO-A0J6
BRCA
TCGA
NASVHQYSVRP
CBL_PTK
0.2222
p.T216M
DO4233
BRCA
ICGC
NASVHQYSVRP
CBL_PTK
0.2222
p.T216M
DO45185
LIRI
ICGC
NASVHQYSVRP
CBL_PTK
0.2222
p.T216M
DO32708
OV
ICGC
NASVHQYSVRP
CBL_PTK
0.2222
p.T216M
SIDM01619
Endometrial Carcinoma
GDSC
NASVHQYSVRP
CBL_PTK
0.2222
p.T216M
ACH-000984
Endometrial/Uterine Cancer
CCLE
NASVHQYSVRP
CBL_PTK
0.2222
p.Y239H
TCGA-86-8585
LUAD
TCGA
NASVHQYSVRP
CBL_PTK
0.0833
p.Y239H
DO24850
LUAD
ICGC
NASVHQYSVRP
CBL_PTK
0.0833
p.T215S
TCGA-AD-6964
COAD
TCGA
NASVHQYSVRP
CBL_PTK
0.1944
p.T215S
DO8360
COAD
ICGC
NASVHQYSVRP
CBL_PTK
0.1944
p.R229H
TCGA-DX-A1L2
SARC
TCGA
NASVHQYSVRP
CBL_PTK
0.7133
p.R229H
TCGA-F1-6177
STAD
TCGA
NASVHQYSVRP
CBL_PTK
0.7133
p.R229H
DO219951
SARC
ICGC
NASVHQYSVRP
CBL_PTK
0.7133
p.R229H
DO38727
STAD
ICGC
NASVHQYSVRP
CBL_PTK
0.7133
p.L233M
TCGA-FS-A1ZZ
SKCM
TCGA
NASVHQYSVRP
CBL_PTK
0.25
p.L233M
DO37412
SKCM
ICGC
NASVHQYSVRP
CBL_PTK
0.25
p.S235A
DO45049
LINC
ICGC
NASVHQYSVRP
CBL_PTK
0.1944
p.G234D
DO220903
MELA
ICGC
NASVHQYSVRP
CBL_PTK
0.2222
p.A221D
SIDM00334
Endometrial Carcinoma
GDSC
NASVHQYSVRP
CBL_PTK
0.6682
p.A221D
ACH-000879
Endometrial/Uterine Cancer
CCLE
NASVHQYSVRP
CBL_PTK
0.6682
p.A221D
MFE-296
endometrium
COSMIC
NASVHQYSVRP
CBL_PTK
0.6682
Drug responses associated with UNC13A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NASVHQYSVRP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPW8
Protein unc-13 homolog A
CBL_PTK
220:230
NASVHQYSVRP
CBL
0.8741
More...