DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPPY
Uniprot ID:
Q92567
Source protein:
Protein FAM168A
Source gene:
FAM168A
Class:
ITCH
Location:
120:123
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.5413
ASA_SCORE:
73.35
COIL:
0.9438
CONS_SCORE:
0.9354
DSS_SCORE:
0.6895
HELIX:
0.0195
FCONS_SCORE:
0.9968
RIG_SCORE:
0.5796
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P116Q
TCGA-CV-7415
HNSC
TCGA
PPPY
ITCH
0.2222
p.I128M
TCGA-EK-A2RJ
CESC
TCGA
PPPY
ITCH
0.1944
p.K110N
DO47578
SKCM
ICGC
PPPY
ITCH
0.1667
p.P113L
DO36397
READ
ICGC
PPPY
ITCH
0.1389
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Drug responses associated with FAM168A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPPY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96DV4
39S ribosomal protein L38, mitochondrial
ITCH
347:350
PPPY
ITCH,NEDD4
0.6466
More...
O15072
A disintegrin and metalloproteinase with thrombospondin motifs 3
ITCH
1058:1061
PPPY
ITCH,NEDD4
0.9797
More...
Q13625
Apoptosis-stimulating of p53 protein 2
ITCH
871:874
PPPY
ITCH,NEDD4
0.9885
More...
P54259
Atrophin-1
ITCH
445:448
PPPY
ITCH,NEDD4
0.973
More...
P54259
Atrophin-1
ITCH
636:639
PPPY
ITCH,NEDD4
0.9909
More...
Q8WXX7
Autism susceptibility gene 2 protein
ITCH
516:519
PPPY
ITCH,NEDD4
0.9979
More...
O00512
B-cell CLL/lymphoma 9 protein
ITCH
515:518
PPPY
ITCH,NEDD4
0.9973
More...
Q86UU0
B-cell CLL/lymphoma 9-like protein
ITCH
561:564
PPPY
ITCH,NEDD4
0.9923
More...
O95395
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
ITCH
285:288
PPPY
ITCH,NEDD4
0.5532
More...
O95415
Brain protein I3
ITCH
39:42
PPPY
ITCH,NEDD4
0.9496
More...
Q15018
BRISC complex subunit Abraxas 2
ITCH
305:308
PPPY
ITCH,NEDD4
0.9939
More...
Q9P203
BTB/POZ domain-containing protein 7
ITCH
762:765
PPPY
ITCH,NEDD4
0.9575
More...
Q9Y6W3
Calpain-7
ITCH
624:627
PPPY
ITCH,NEDD4
0.5393
More...
Q8WXE0
Caskin-2
ITCH
751:754
PPPY
ITCH,NEDD4
0.6879
More...
Q9H305
Cell death-inducing p53-target protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9945
More...
Q9H305
Cell death-inducing p53-target protein 1
ITCH
51:54
PPPY
ITCH,NEDD4
0.9943
More...
Q16630
Cleavage and polyadenylation specificity factor subunit 6
ITCH
387:390
PPPY
ITCH,NEDD4
0.9919
More...
Q8WXI2
Connector enhancer of kinase suppressor of ras 2
ITCH
704:707
PPPY
ITCH,NEDD4
0.9478
More...
Q86YQ8
Copine-8
ITCH
550:553
PPPY
ITCH,NEDD4
0.743
More...
Q6UUV7
CREB-regulated transcription coactivator 3
ITCH
445:448
PPPY
ITCH,NEDD4
0.998
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
113:116
PPPY
ITCH,NEDD4
0.9396
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
129:132
PPPY
ITCH,NEDD4
0.9428
More...
Q96J86
Cysteine and tyrosine-rich protein 1
ITCH
145:148
PPPY
ITCH,NEDD4
0.9794
More...
Q9H1C7
Cysteine-rich and transmembrane domain-containing protein 1
ITCH
6:9
PPPY
ITCH,NEDD4
0.9391
More...
Q9BTC0
Death-inducer obliterator 1
ITCH
1817:1820
PPPY
ITCH,NEDD4
0.9967
More...
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