DegronMD - Q86UU5(GGN)

FUNCTION: May be involved in spermatogenesis. {ECO:0000250}.

GO - Biological processes (BP): cell differentiation [GO:0030154]; double-strand break repair [GO:0006302]; gamete generation [GO:0007276]; spermatogenesis [GO:0007283]

GO - Molecular function (MF): ubiquitin protein ligase binding [GO:0031625]

GO - Cellular component (CC):

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S260R	SIDM01617	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.8538
p.S260R	ACH-000994	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.8538
p.S261F	DO222824	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.7982
p.H544N	DO228474	LICA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.7423
p.H544N	DO228806	LICA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.7423
p.T444K	DO229025	LICA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.7306
p.P338T	DO229034	LICA	ICGC	PPPY	ITCH	338:341	Mutation altering degron motif	0.7031
p.P442L	TCGA-VQ-A91D	STAD	TCGA	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.6471
p.P442L	DO51783	STAD	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.6471
p.P447L	DO50970	LICA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.6471
p.L543V	TCGA-55-6642	LUAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.5654
p.L543V	DO23622	LUAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.5654
p.P256Q	TCGA-D3-A2J6	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.3056
p.P256Q	DO37901	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.3056
p.R539C	DO224764	PACA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00654	Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00210	Ovarian Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00650	Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 74 entries

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Kaplan plot for GGN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GGN

UniProt ID: Q86UU5

Entrez ID: 199720

Protein name: Gametogenetin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GGN in