DegronMD - Q86UU5(GGN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R549H	TCGA-2W-A8YY	CESC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.25
p.R549H	DO223732	CESC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.25
p.A537T	TCGA-32-2616	GBM	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.25
p.A537T	DO13462	GBM	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.25
p.S267L	TCGA-53-7624	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1667
p.S267L	TCGA-AG-A002	READ	TCGA	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1667
p.S267L	DO25058	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1667
p.L543V	TCGA-55-6642	LUAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.5654
p.L543V	DO23622	LUAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.5654
p.P438L	TCGA-55-A490	LUAD	TCGA	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.25
p.P438L	DO24596	LUAD	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.25
p.T538I	TCGA-A6-6781	COAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.2778
p.T538I	DO8447	COAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.2778
p.E550K	TCGA-AA-3977	COAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.2222
p.E550K	DO8730	COAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.2222
p.A333D	TCGA-AL-3472	KIRP	TCGA	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1944
p.A333D	DO20923	KIRP	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1944
p.S347L	TCGA-AP-A1DV	UCEC	TCGA	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1667
p.S347L	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1667
p.S347L	DO43186	UCEC	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1667
p.S347L	DO43755	UCEC	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1667
p.R334W	TCGA-BR-8682	STAD	TCGA	PPPY	ITCH	338:341	Mutation rewiring degron network	0.2222
p.R334W	DO223070	ESCA	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.2222
p.R334W	DO47737	STAD	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.2222
p.A264V	TCGA-CV-A45W	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.25
p.A264V	DO52060	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.25
p.A552S	TCGA-D1-A101	UCEC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.1667
p.A552S	DO43955	UCEC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.1667
p.P256Q	TCGA-D3-A2J6	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.3056
p.P256Q	DO37901	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.3056
p.P345Q	TCGA-DA-A1IB	SKCM	TCGA	PPPY	ITCH	338:341	Mutation rewiring degron network	0.2222
p.P345Q	DO38033	SKCM	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.2222
p.R549C	TCGA-EY-A2OP	UCEC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.25
p.R549C	DO42560	UCEC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.25
p.T555A	TCGA-HU-A4GQ	STAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.0833
p.T555A	DO47767	STAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.0833
p.P442L	TCGA-VQ-A91D	STAD	TCGA	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.6471
p.P442L	DO51783	STAD	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.6471
p.V556E	TCGA-VS-A9U6	CESC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.0556
p.V556E	DO219728	CESC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.0556
p.F247L	DO224971	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.F247L	DO52554	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.G270D	DO228483	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0833
p.A554T	DO230335	COCA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.1111
p.A328V	DO234187	ESAD	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.0556
p.A453V	DO233163	GACA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.1944
p.A453V	DO52132	PAEN	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.1944
p.A453V	ACH-000982	Colon/Colorectal Cancer	CCLE	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.1944
p.A453V	ACH-001345	Colon/Colorectal Cancer	CCLE	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.1944
p.H544N	DO228474	LICA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.7423
p.H544N	DO228806	LICA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation altering degron motif	0.7423
p.T444K	DO229025	LICA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.7306
p.F351L	DO229027	LICA	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.0556
p.P338T	DO229034	LICA	ICGC	PPPY	ITCH	338:341	Mutation altering degron motif	0.7031
p.P447L	DO50970	LICA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation altering degron motif	0.6471
p.E436K	DO220911	MELA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.1944
p.S261F	DO222824	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.7982
p.R539C	DO224764	PACA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.P255S	DO229163	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2778
p.P439Q	DO229272	THCA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	441:448	Mutation rewiring degron network	0.2778
p.P349L	DO229248	THCA	ICGC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1111
p.G547S	SIDM00654	Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00210	Ovarian Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00650	Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.G547S	SIDM01681	Non-Cancerous	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.3056
p.A330V	SIDM01051	Ovarian Carcinoma	GDSC	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1111
p.A330V	ACH-000936	Ovarian Cancer	CCLE	PPPY	ITCH	338:341	Mutation rewiring degron network	0.1111
p.R532C	SIDM00217	Colorectal Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.1111
p.R532C	ACH-000999	Colon/Colorectal Cancer	CCLE	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.1111
p.R532C	SNU-1040	large intestine	COSMIC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	540:546	Mutation rewiring degron network	0.1111
p.S260R	SIDM01617	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.8538
p.S260R	ACH-000994	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.8538

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GGN

UniProt ID: Q86UU5

Entrez ID: 199720

Protein name: Gametogenetin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GGN in