DegronMD

Uniprot ID: Q86UU5

Source protein: Gametogenetin

Source gene: GGN

Class: DEG_SCF_FBW7_1

Location: 441:448

E3 ligase: FBXW7

DEGRON score: 0.9909

ASA_SCORE: 97.0625

COIL: 0.9759

CONS_SCORE: 0.7573

DSS_SCORE: 0.8237

HELIX: 0.0115

FCONS_SCORE: 1.2009

RIG_SCORE: 0.5049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P438L	TCGA-55-A490	LUAD	TCGA	PPPTPPPT	DEG_SCF_FBW7_1	0.25
p.P438L	DO24596	LUAD	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.25
p.P442L	TCGA-VQ-A91D	STAD	TCGA	PPPTPPPT	DEG_SCF_FBW7_1	0.6471
p.P442L	DO51783	STAD	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.6471
p.A453V	DO233163	GACA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.1944
p.A453V	DO52132	PAEN	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.1944
p.A453V	ACH-000982	Colon/Colorectal Cancer	CCLE	PPPTPPPT	DEG_SCF_FBW7_1	0.1944
p.A453V	ACH-001345	Colon/Colorectal Cancer	CCLE	PPPTPPPT	DEG_SCF_FBW7_1	0.1944
p.T444K	DO229025	LICA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.7306
p.P447L	DO50970	LICA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.6471
p.E436K	DO220911	MELA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.1944
p.P439Q	DO229272	THCA	ICGC	PPPTPPPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU5	Gametogenetin	DEG_SCF_FBW7_1	441:448	PPPTPPPT	FBXW7	0.9909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons