DegronMD

Uniprot ID: Q86UU5

Source protein: Gametogenetin

Source gene: GGN

Class: LIG_APCC_ABBAyCdc20_2

Location: 540:546

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6957

ASA_SCORE: 95.5286

COIL: 0.9351

CONS_SCORE: 0.6088

DSS_SCORE: 0.7714

HELIX: 0.0267

FCONS_SCORE: 0.8839

RIG_SCORE: 0.6056

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R549H	TCGA-2W-A8YY	CESC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.R549H	DO223732	CESC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.A537T	TCGA-32-2616	GBM	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.A537T	DO13462	GBM	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.L543V	TCGA-55-6642	LUAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.5654
p.L543V	DO23622	LUAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.5654
p.T538I	TCGA-A6-6781	COAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T538I	DO8447	COAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E550K	TCGA-AA-3977	COAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E550K	DO8730	COAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A552S	TCGA-D1-A101	UCEC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.A552S	DO43955	UCEC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R549C	TCGA-EY-A2OP	UCEC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.R549C	DO42560	UCEC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.T555A	TCGA-HU-A4GQ	STAD	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T555A	DO47767	STAD	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V556E	TCGA-VS-A9U6	CESC	TCGA	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.V556E	DO219728	CESC	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A554T	DO230335	COCA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.H544N	DO228474	LICA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.7423
p.H544N	DO228806	LICA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.7423
p.R539C	DO224764	PACA	ICGC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G547S	SIDM00654	Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G547S	SIDM00210	Ovarian Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G547S	SIDM00650	Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G547S	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G547S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G547S	SIDM01681	Non-Cancerous	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R532C	SIDM00217	Colorectal Carcinoma	GDSC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R532C	ACH-000999	Colon/Colorectal Cancer	CCLE	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R532C	SNU-1040	large_intestine	COSMIC	KDGLHGD	LIG_APCC_ABBAyCdc20_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KDGLHGD

Degron related mutations and impact score

Drug responses associated with GGN mutations

All proteins holding degron of KDGLHGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU5	Gametogenetin	LIG_APCC_ABBAyCdc20_2	540:546	KDGLHGD	APC,CDC20,FZR1	0.6957	More...