DegronMD - P48634(PRRC2A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G138R	TCGA-13-1498	OV	TCGA	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation altering degron motif	0.7568
p.G138R	DO30180	OV	ICGC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation altering degron motif	0.7568
p.K1814T	TCGA-17-Z015	LUAD	TCGA	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation blocking ubiquitination signal	0.6944
p.E824K	TCGA-17-Z026	LUAD	TCGA	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1389
p.S1808F	TCGA-18-3409	LUSC	TCGA	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.0833
p.S1808F	DO26444	LUSC	ICGC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.0833
p.S1808F	SIDM00864	Cervical Carcinoma	GDSC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.0833
p.G1552E	TCGA-2H-A9GO	ESCA	TCGA	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.2778
p.P122L	TCGA-32-2616	GBM	TCGA	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.P122L	DO13462	GBM	ICGC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.R722L	TCGA-33-4587	LUSC	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.2222
p.R722L	DO27683	LUSC	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.2222
p.G737C	TCGA-44-2657	LUAD	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1667
p.G737C	DO25020	LUAD	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1667
p.A1551S	TCGA-69-7978	LUAD	TCGA	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.3056
p.A1551S	DO24920	LUAD	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.3056
p.D720N	TCGA-78-7150	LUAD	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1667
p.D720N	DO24411	LUAD	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1667
p.S761I	TCGA-AA-3663	COAD	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation altering degron motif	0.8453
p.S761I	DO9346	COAD	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation altering degron motif	0.8453
p.L259I	TCGA-AG-A002	READ	TCGA	PPPY	ITCH	262:265	Mutation rewiring degron network	0.25
p.L259I	TCGA-AX-A2HC	UCEC	TCGA	PPPY	ITCH	262:265	Mutation rewiring degron network	0.25
p.L259I	DO41572	UCEC	ICGC	PPPY	ITCH	262:265	Mutation rewiring degron network	0.25
p.L259I	ACH-000545	Bladder Cancer	CCLE	PPPY	ITCH	262:265	Mutation rewiring degron network	0.25
p.K49N	TCGA-AP-A051	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.3056
p.K49N	DO42673	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.3056
p.R55H	TCGA-AP-A0LM	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1389
p.R55H	DO43306	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1389
p.V147I	TCGA-AX-A3G9	UCEC	TCGA	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	DO41241	UCEC	ICGC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	SIDM00215	Colorectal Carcinoma	GDSC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	SIDM00489	Oral Cavity Carcinoma	GDSC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	SIDM00324	Neuroblastoma	GDSC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	TGW	autonomic ganglia	COSMIC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	KYSE-220	oesophagus	COSMIC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	Ca9-22	upper aerodigestive tract	COSMIC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.V147I	SNU-283	large intestine	COSMIC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1111
p.R272Q	TCGA-B5-A0JZ	UCEC	TCGA	PPPY	ITCH	262:265	Mutation rewiring degron network	0.1389
p.R272Q	DO42761	UCEC	ICGC	PPPY	ITCH	262:265	Mutation rewiring degron network	0.1389
p.R1560C	TCGA-B5-A3FC	UCEC	TCGA	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.0556
p.R1560C	DO41871	UCEC	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.0556
p.P728L	TCGA-BF-A5EO	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.6471
p.P728L	DO219450	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.6471
p.R758C	TCGA-BK-A6W3	UCEC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.2778
p.R758C	DO50076	UCEC	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.2778
p.A539V	TCGA-BQ-7044	KIRP	TCGA	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.3056
p.A539V	DO20942	KIRP	ICGC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.3056
p.P1823Q	TCGA-BR-4201	STAD	TCGA	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.7035
p.P1823Q	DO38707	STAD	ICGC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.7035
p.R722Q	TCGA-BR-6852	STAD	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.2222
p.R722Q	DO38202	STAD	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.2222
p.P755S	TCGA-CF-A9FF	BLCA	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.1944
p.P755S	DO218999	BLCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.1944
p.L2045F	TCGA-CN-6010	HNSC	TCGA	GRAELHPVE	DEG_APCC_DBOX_1	2046:2054	Mutation rewiring degron network	0.3056
p.L2045F	TCGA-CN-6010	HNSC	TCGA	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation rewiring degron network	0.0556
p.L2045F	DO14766	HNSC	ICGC	GRAELHPVE	DEG_APCC_DBOX_1	2046:2054	Mutation rewiring degron network	0.3056
p.L2045F	DO14766	HNSC	ICGC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation rewiring degron network	0.0556
p.P728S	TCGA-CN-6992	HNSC	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.6752
p.P728S	DO14606	HNSC	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.6752
p.S823N	TCGA-CV-7410	HNSC	TCGA	PPPY	ITCH	831:834	Mutation blocking phosphorylation signal	0.5556
p.S823N	DO14790	HNSC	ICGC	PPPY	ITCH	831:834	Mutation blocking phosphorylation signal	0.5556
p.Q736H	TCGA-D3-A2JC	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1944
p.Q736H	DO47578	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1944
p.R756Q	TCGA-D8-A1JA	BRCA	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.2222
p.R756Q	DO2819	BRCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.2222
p.R756Q	DO222765	COCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.2222
p.R756Q	DO233254	GACA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.2222
p.P1637L	TCGA-DA-A1IC	SKCM	TCGA	LSPFED	LIG_APCC_ABBA_1	1635:1640	Mutation altering degron motif	0.6471
p.P1637L	TCGA-QB-A6FS	SKCM	TCGA	LSPFED	LIG_APCC_ABBA_1	1635:1640	Mutation altering degron motif	0.6471
p.P1637L	DO37430	SKCM	ICGC	LSPFED	LIG_APCC_ABBA_1	1635:1640	Mutation altering degron motif	0.6471
p.P1637L	DO48654	SKCM	ICGC	LSPFED	LIG_APCC_ABBA_1	1635:1640	Mutation altering degron motif	0.6471
p.L735F	TCGA-DA-A95Z	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.2222
p.L735F	DO219481	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.2222
p.P727S	TCGA-DD-A1EJ	LIHC	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.5641
p.P727S	DO22994	LIHC	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.5641
p.L259F	TCGA-DU-6392	LGG	TCGA	PPPY	ITCH	262:265	Mutation rewiring degron network	0.25
p.L259F	DO22237	LGG	ICGC	PPPY	ITCH	262:265	Mutation rewiring degron network	0.25
p.A550T	TCGA-DU-6392	LGG	TCGA	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.1944
p.A550T	DO22237	LGG	ICGC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.1944
p.A836V	TCGA-DU-6392	LGG	TCGA	PPPY	ITCH	831:834	Mutation rewiring degron network	0.2778
p.A836V	DO22237	LGG	ICGC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.2778
p.A836V	ACH-001142	Non-Cancerous	CCLE	PPPY	ITCH	831:834	Mutation rewiring degron network	0.2778
p.S2066I	TCGA-DX-A8BG	SARC	TCGA	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation rewiring degron network	0.1667
p.S2066I	DO220042	SARC	ICGC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation rewiring degron network	0.1667
p.L741I	TCGA-EE-A2MJ	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0556
p.L741I	DO38099	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0556
p.P826S	TCGA-EE-A2MS	SKCM	TCGA	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P826S	DO37567	SKCM	ICGC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P826S	SIDM01151	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P826S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P826S	ACH-000483	Liver Cancer	CCLE	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P826S	ACH-000843	Lung Cancer	CCLE	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P826S	SNU-182	liver	COSMIC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P826S	HARA	lung	COSMIC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.E843D	TCGA-EK-A3GK	CESC	TCGA	PPPY	ITCH	831:834	Mutation rewiring degron network	0.0833
p.E843D	DO49964	CESC	ICGC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.0833
p.P2057L	TCGA-G4-6302	COAD	TCGA	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.6471
p.P2057L	DO8778	COAD	ICGC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.6471
p.P2057L	DO50733	ORCA	ICGC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.6471
p.P2057L	SIDM02021	Esophageal Carcinoma	GDSC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.6471
p.E1645Q	TCGA-GV-A3JX	BLCA	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1650:1656	Mutation rewiring degron network	0.1944
p.E1645Q	TCGA-GV-A3JX	BLCA	TCGA	LSPFED	LIG_APCC_ABBA_1	1635:1640	Mutation rewiring degron network	0.1944
p.E1645Q	DO448	BLCA	ICGC	DSGVDLS	DEG_SCF_TRCP1_1	1650:1656	Mutation rewiring degron network	0.1944
p.E1645Q	DO448	BLCA	ICGC	LSPFED	LIG_APCC_ABBA_1	1635:1640	Mutation rewiring degron network	0.1944
p.F2041L	TCGA-N9-A4Q7	UCS	TCGA	GRAELHPVE	DEG_APCC_DBOX_1	2046:2054	Mutation rewiring degron network	0.1944
p.P1823S	TCGA-QC-A7B5	SARC	TCGA	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.6752
p.P1823S	DO220239	SARC	ICGC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.6752
p.P1823L	TCGA-QC-A7B5	SARC	TCGA	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.7582
p.P1823L	DO220239	SARC	ICGC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.7582
p.P1823L	SIDM00370	T-Lymphoblastic Leukemia	GDSC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.7582
p.P1823L	SIDM00616	Hepatocellular Carcinoma	GDSC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.7582
p.P1823L	SIDM00166	Other Solid Cancers	GDSC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation altering degron motif	0.7582
p.S766T	TCGA-W3-AA1Q	SKCM	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation altering degron motif	0.7116
p.S766T	DO219487	SKCM	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation altering degron motif	0.7116
p.F2058L	DO225192	BRCA	ICGC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.6981
p.G1552R	DO50329	ESAD	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.2778
p.L753V	DO234408	ESAD	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.1389
p.R54W	DO223074	ESCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1667
p.P57S	DO233058	GACA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.0833
p.R1548W	DO233737	GACA	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation altering degron motif	0.7523
p.V139I	DO233747	GACA	ICGC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation altering degron motif	0.5965
p.R2047L	DO228288	LICA	ICGC	GRAELHPVE	DEG_APCC_DBOX_1	2046:2054	Mutation altering degron motif	0.8428
p.P826A	DO45217	LIRI	ICGC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.1944
p.P136S	DO228326	MALY	ICGC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation altering degron motif	0.6752
p.P263L	DO220852	MELA	ICGC	PPPY	ITCH	262:265	Mutation altering degron motif	0.7582
p.P1558S	DO220878	MELA	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.1111
p.PP1557PS	DO220878	MELA	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0
p.M1632V	DO220896	MELA	ICGC	LSPFED	LIG_APCC_ABBA_1	1635:1640	Mutation rewiring degron network	0.25
p.P262S	DO220899	MELA	ICGC	PPPY	ITCH	262:265	Mutation altering degron motif	0.6752
p.P554S	DO220911	MELA	ICGC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.0833
p.E32K	DO32831	PACA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1111
p.G1664D	DO232761	PBCA	ICGC	DSGVDLS	DEG_SCF_TRCP1_1	1650:1656	Mutation rewiring degron network	0.1111
p.S1651G	DO229181	THCA	ICGC	DSGVDLS	DEG_SCF_TRCP1_1	1650:1656	Mutation altering degron motif	0.6993
p.Q45R	DO229199	THCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6218
p.L1832M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.1389
p.L1832M	ACH-000981	Leukemia	CCLE	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.1389
p.L1832M	DND-41	haematopoietic and lymphoid tissue	COSMIC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.1389
p.P827Q	SIDM00499	Prostate Carcinoma	GDSC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.2222
p.P827Q	22RV1	prostate	COSMIC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.2222
p.A127T	SIDM00845	Burkitt's Lymphoma	GDSC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.25
p.A127T	ACH-000786	Lymphoma	CCLE	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.25
p.A127T	ACH-001067	Brain Cancer	CCLE	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.25
p.L134S	SIDM00845	Burkitt's Lymphoma	GDSC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation altering degron motif	0.6556
p.R1831H	SIDM00781	Colorectal Carcinoma	GDSC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.1667
p.R1831H	ACH-001199	Colon/Colorectal Cancer	CCLE	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.1667
p.R1831H	SNU-C2B	large intestine	COSMIC	DSGHCVPEP	DEG_COP1_1	1817:1825	Mutation rewiring degron network	0.1667
p.L2055P	SIDM00185	Melanoma	GDSC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.7582
p.L2055P	ACH-002152	Skin Cancer	CCLE	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.7582
p.L2055P	LB2518-MEL	skin	COSMIC	LKPFQD	LIG_APCC_ABBA_1	2055:2060	Mutation altering degron motif	0.7582
p.Y255C	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	262:265	Mutation rewiring degron network	0.1389
p.Y255C	ACH-002263	Esophageal Cancer	CCLE	PPPY	ITCH	262:265	Mutation rewiring degron network	0.1389
p.Y255C	KYSE-220	oesophagus	COSMIC	PPPY	ITCH	262:265	Mutation rewiring degron network	0.1389
p.P554L	SIDM00007	Other Solid Cancers	GDSC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.0833
p.P554L	ACH-001550	Skin Cancer	CCLE	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.0833
p.P554L	MCC13	skin	COSMIC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.0833
p.M254V	SIDM00890	Melanoma	GDSC	PPPY	ITCH	262:265	Mutation rewiring degron network	0.1111
p.M254V	C32	skin	COSMIC	PPPY	ITCH	262:265	Mutation rewiring degron network	0.1111
p.A37T	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.25
p.A37T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.25
p.P535A	SIDM00498	Colorectal Carcinoma	GDSC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.1944
p.P535A	ACH-000970	Colon/Colorectal Cancer	CCLE	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.1944
p.P535A	SNU-C5	large intestine	COSMIC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.1944
p.E547K	SIDM00920	Breast Carcinoma	GDSC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.2778
p.E547K	ACH-000783	Breast Cancer	CCLE	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.2778
p.E547K	CAMA-1	breast	COSMIC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.2778
p.R822G	SIDM01159	Other Sarcomas	GDSC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.0833
p.R822G	SW872	soft tissue	COSMIC	PPPY	ITCH	831:834	Mutation rewiring degron network	0.0833
p.S146N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation blocking phosphorylation signal	0.5833
p.S146N	ACH-001737	Leukemia	CCLE	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation blocking phosphorylation signal	0.5833
p.S146N	ACH-002222	Leukemia	CCLE	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation blocking phosphorylation signal	0.5833
p.S146N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation blocking phosphorylation signal	0.5833
p.T541I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation altering degron motif	0.7078
p.T541I	ACH-002222	Leukemia	CCLE	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation altering degron motif	0.7078
p.T541I	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation altering degron motif	0.7078
p.A539T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.3056
p.A539T	ACH-000937	Leukemia	CCLE	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.3056
p.A539T	PF-382	haematopoietic and lymphoid tissue	COSMIC	PTPETE	DEG_SCF_FBW7_2	540:545	Mutation rewiring degron network	0.3056
p.P1557T	SIDM01578	Bladder Carcinoma	GDSC	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.1389
p.P1557T	ACH-000862	Bladder Cancer	CCLE	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation rewiring degron network	0.1389
p.Q144K	ACH-000679	Esophageal Cancer	CCLE	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation rewiring degron network	0.1944
p.V1543L	ACH-000710	Lung Cancer	CCLE	VGGTPRDS	DEG_SCF_FBW7_1	1543:1550	Mutation altering degron motif	0.5654
p.P755A	ACH-000849	Breast Cancer	CCLE	DSGGSSS	DEG_SCF_TRCP1_1	760:766	Mutation rewiring degron network	0.1944
p.P133L	ACH-001551	Skin Cancer	CCLE	ENTPLVPSGV	DEG_COP1_1	130:139	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRC2A

UniProt ID: P48634

Entrez ID: 7916

Protein name: Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRC2A in