DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: LIG_APCC_ABBA_1

Location: 726:731

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8824

ASA_SCORE: 107.4833

COIL: 0.9767

CONS_SCORE: 0.6824

DSS_SCORE: 0.3295

HELIX: 0.0138

FCONS_SCORE: 0.9761

RIG_SCORE: 0.8033

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R722L	TCGA-33-4587	LUSC	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.2222
p.R722L	DO27683	LUSC	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.2222
p.G737C	TCGA-44-2657	LUAD	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.1667
p.G737C	DO25020	LUAD	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.1667
p.D720N	TCGA-78-7150	LUAD	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.1667
p.D720N	DO24411	LUAD	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.1667
p.P728L	TCGA-BF-A5EO	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.6471
p.P728L	DO219450	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.6471
p.R722Q	TCGA-BR-6852	STAD	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.2222
p.R722Q	DO38202	STAD	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.2222
p.P728S	TCGA-CN-6992	HNSC	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.6752
p.P728S	DO14606	HNSC	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.6752
p.Q736H	TCGA-D3-A2JC	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.1944
p.Q736H	DO47578	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.1944
p.L735F	TCGA-DA-A95Z	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.2222
p.L735F	DO219481	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.2222
p.P727S	TCGA-DD-A1EJ	LIHC	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.5641
p.P727S	DO22994	LIHC	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.5641
p.L741I	TCGA-EE-A2MJ	SKCM	TCGA	IPPYVD	LIG_APCC_ABBA_1	0.0556
p.L741I	DO38099	SKCM	ICGC	IPPYVD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	LIG_APCC_ABBA_1	726:731	IPPYVD	APC,CDC20,FZR1	0.8824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons