DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_APCC_DBOX_1

Location: 2046:2054

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9901

ASA_SCORE: 98.4556

COIL: 0.8571

CONS_SCORE: 0.5888

DSS_SCORE: 0.4875

HELIX: 0.0929

FCONS_SCORE: 1.0039

RIG_SCORE: 0.7071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2045F	TCGA-CN-6010	HNSC	TCGA	GRAELHPVE	DEG_APCC_DBOX_1	0.3056
p.L2045F	DO14766	HNSC	ICGC	GRAELHPVE	DEG_APCC_DBOX_1	0.3056
p.F2041L	TCGA-N9-A4Q7	UCS	TCGA	GRAELHPVE	DEG_APCC_DBOX_1	0.1944
p.R2047L	DO228288	LICA	ICGC	GRAELHPVE	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_APCC_DBOX_1	2046:2054	GRAELHPVE	APC,CDC20,FZR1	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons