DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_SCF_TRCP1_1

Location: 760:766

E3 ligase: BTRC

DEGRON score: 0.9953

ASA_SCORE: 81

COIL: 0.9693

CONS_SCORE: 0.699

DSS_SCORE: 0.7212

HELIX: 0.025

FCONS_SCORE: 1.0532

RIG_SCORE: 0.4671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S761I	TCGA-AA-3663	COAD	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.8453
p.S761I	DO9346	COAD	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.8453
p.R758C	TCGA-BK-A6W3	UCEC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.2778
p.R758C	DO50076	UCEC	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.2778
p.P755S	TCGA-CF-A9FF	BLCA	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.1944
p.P755S	DO218999	BLCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.1944
p.R756Q	TCGA-D8-A1JA	BRCA	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.2222
p.R756Q	DO2819	BRCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.2222
p.R756Q	DO222765	COCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.2222
p.R756Q	DO233254	GACA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.2222
p.S766T	TCGA-W3-AA1Q	SKCM	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.7116
p.S766T	DO219487	SKCM	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.7116
p.L753V	DO234408	ESAD	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.1389
p.P755A	ACH-000849	Breast Cancer	CCLE	DSGGSSS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_SCF_TRCP1_1	760:766	DSGGSSS	BTRC	0.9953	More...
Q96KG7	Multiple epidermal growth factor-like domains protein 10	DEG_SCF_TRCP1_1	1127:1133	DSGGSSS	BTRC	0.9746	More...
Q969W3	Protein FAM104A	DEG_SCF_TRCP1_1	112:118	DSGGSSS	BTRC	0.9611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons