DegronMD - Q969W3(FAM104A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L87I	TCGA-75-5126	LUAD	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.0833
p.L87I	DO23711	LUAD	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.0833
p.E117Q	TCGA-A2-A0YL	BRCA	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	112:118	Mutation altering degron motif	0.6744
p.T91I	TCGA-AJ-A3EK	UCEC	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1944
p.T91I	DO41584	UCEC	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1944
p.S115I	TCGA-AP-A0LM	UCEC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	112:118	Mutation altering degron motif	0.7341
p.E175K	TCGA-AX-A2HC	UCEC	TCGA	LQHRGR	SCF_FBXL2	178:183	Mutation rewiring degron network	0.25
p.A125E	TCGA-B5-A0K9	UCEC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	112:118	Mutation rewiring degron network	0.1389
p.L53F	TCGA-BA-5152	HNSC	TCGA	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.587
p.L53F	DO14393	HNSC	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.587
p.P88L	TCGA-D7-8579	STAD	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1111
p.P88L	DO47985	STAD	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1111
p.P88L	SIDM00118	Colorectal Carcinoma	GDSC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1111
p.P88L	HCC2998	large intestine	COSMIC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1111
p.P51S	TCGA-EB-A3XC	SKCM	TCGA	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.6752
p.P51S	DO37579	SKCM	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.6752
p.P98S	TCGA-EE-A2GR	SKCM	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.5641
p.P98S	DO37996	SKCM	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.5641
p.S52C	TCGA-EK-A2RM	CESC	TCGA	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.7541
p.S52C	DO49956	CESC	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.7541
p.S52F	TCGA-GS-A9TZ	DLBC	TCGA	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.7982
p.S52F	DO219918	DLBC	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.7982
p.A128V	TCGA-RC-A7SB	LIHC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	112:118	Mutation rewiring degron network	0.0556
p.R100Q	DO10639	COAD	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7329
p.R93I	DO230313	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.25
p.R106Q	DO227646	COCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	112:118	Mutation rewiring degron network	0.1667
p.R106Q	DO227646	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.2222
p.G53R	DO222765	COCA	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.7568
p.I98T	DO229010	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO229013	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO229016	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO229003	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO229005	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO229480	LAML	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO228957	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO231091	LUSC	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.I98T	DO231155	LUSC	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7078
p.E44Q	DO16678	KIRC	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.2778
p.P63H	DO228976	LICA	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.0556
p.N57K	DO228971	LICA	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.2222
p.H86N	DO229028	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.0556
p.A56E	DO229025	LICA	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.25
p.S87R	DO229027	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.0833
p.S55R	DO229035	LICA	ICGC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.2778
p.H90N	DO229045	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1667
p.S97A	DO229051	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation altering degron motif	0.7588
p.P89S	DO35350	PACA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1389
p.P48R	SIDM01141	Ovarian Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.6401
p.G41V	SIDM00617	Hepatocellular Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM00075	Non-Cancerous	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM00552	Rhabdomyosarcoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM01653	Non-Cancerous	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM00271	Gastric Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM01372	Pancreatic Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM01608	Endometrial Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM01617	Endometrial Carcinoma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.G41V	SIDM01473	Plasma Cell Myeloma	GDSC	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1944
p.T91A	SIDM00217	Colorectal Carcinoma	GDSC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	96:102	Mutation rewiring degron network	0.1944
p.R36P	ACH-000490	Cervical Cancer	CCLE	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.0556
p.T47A	ACH-000969	Colon/Colorectal Cancer	CCLE	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.825
p.S60G	ACH-002080	Neuroblastoma	CCLE	TTPSVPSL	DEG_COP1_1	46:53	Mutation rewiring degron network	0.1389
p.P48L	ACH-002512	Skin Cancer	CCLE	TTPSVPSL	DEG_COP1_1	46:53	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM104A

UniProt ID: Q969W3

Entrez ID: 84923

Protein name: Protein FAM104A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM104A in