DegronMD

Uniprot ID: Q969W3

Source protein: Protein FAM104A

Source gene: FAM104A

Class: LIG_APCC_ABBAyCdc20_2

Location: 96:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.549

ASA_SCORE: 72.1714

COIL: 0.7844

CONS_SCORE: 0.7216

DSS_SCORE: 0.7278

HELIX: 0.1414

FCONS_SCORE: 0.9468

RIG_SCORE: 0.6416

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L87I	TCGA-75-5126	LUAD	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L87I	DO23711	LUAD	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T91I	TCGA-AJ-A3EK	UCEC	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.T91I	DO41584	UCEC	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P88L	TCGA-D7-8579	STAD	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P88L	DO47985	STAD	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P88L	SIDM00118	Colorectal Carcinoma	GDSC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P88L	HCC2998	large_intestine	COSMIC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P98S	TCGA-EE-A2GR	SKCM	TCGA	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.5641
p.P98S	DO37996	SKCM	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.5641
p.R100Q	DO10639	COAD	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R93I	DO230313	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.25
p.R106Q	DO227646	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.2222
p.I98T	DO229010	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO229013	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO229016	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO229003	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO229005	COCA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO229480	LAML	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO228957	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO231091	LUSC	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.I98T	DO231155	LUSC	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.H86N	DO229028	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S87R	DO229027	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.H90N	DO229045	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S97A	DO229051	LICA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.7588
p.P89S	DO35350	PACA	ICGC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1389
p.T91A	SIDM00217	Colorectal Carcinoma	GDSC	RNPVFQD	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RNPVFQD

Degron related mutations and impact score

Drug responses associated with FAM104A mutations

All proteins holding degron of RNPVFQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969W3	Protein FAM104A	LIG_APCC_ABBAyCdc20_2	96:102	RNPVFQD	APC,CDC20,FZR1	0.549	More...