DegronMD

Uniprot ID: Q969W3

Source protein: Protein FAM104A

Source gene: FAM104A

Class: DEG_SCF_TRCP1_1

Location: 112:118

E3 ligase: BTRC

DEGRON score: 0.9611

ASA_SCORE: 82.0714

COIL: 0.9567

CONS_SCORE: 0.7399

DSS_SCORE: 0.6784

HELIX: 0.028

FCONS_SCORE: 0.8829

RIG_SCORE: 0.4231

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E117Q	TCGA-A2-A0YL	BRCA	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.6744
p.S115I	TCGA-AP-A0LM	UCEC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.7341
p.A125E	TCGA-B5-A0K9	UCEC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.1389
p.A128V	TCGA-RC-A7SB	LIHC	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.0556
p.R106Q	DO227646	COCA	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_SCF_TRCP1_1	760:766	DSGGSSS	BTRC	0.9953	More...
Q96KG7	Multiple epidermal growth factor-like domains protein 10	DEG_SCF_TRCP1_1	1127:1133	DSGGSSS	BTRC	0.9746	More...
Q969W3	Protein FAM104A	DEG_SCF_TRCP1_1	112:118	DSGGSSS	BTRC	0.9611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons