DegronMD

Uniprot ID: Q96KG7

Source protein: Multiple epidermal growth factor-like domains protein 10

Source gene: MEGF10

Class: DEG_SCF_TRCP1_1

Location: 1127:1133

E3 ligase: BTRC

DEGRON score: 0.9746

ASA_SCORE: 75.8857

COIL: 0.9469

CONS_SCORE: 0.2989

DSS_SCORE: 0.7871

HELIX: 0.0357

FCONS_SCORE: 0.8887

RIG_SCORE: 0.4462

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1128T	TCGA-13-1403	OV	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.8227
p.S1128T	DO28038	OV	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.8227
p.D1127Y	TCGA-97-7546	LUAD	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.7325
p.D1127Y	DO23762	LUAD	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.7325
p.S1120L	TCGA-EE-A182	SKCM	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.1389
p.S1120L	DO37814	SKCM	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.1389
p.S1121F	TCGA-WE-A8JZ	SKCM	TCGA	DSGGSSS	DEG_SCF_TRCP1_1	0.1667
p.S1121F	DO51279	SKCM	ICGC	DSGGSSS	DEG_SCF_TRCP1_1	0.1667
p.S1131G	SIDM00216	Colorectal Carcinoma	GDSC	DSGGSSS	DEG_SCF_TRCP1_1	0.5882
p.S1131G	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGGSSS	DEG_SCF_TRCP1_1	0.5882
p.S1133T	SIDM00084	Glioblastoma	GDSC	DSGGSSS	DEG_SCF_TRCP1_1	0.7116
p.S1128I	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	DSGGSSS	DEG_SCF_TRCP1_1	0.8453
p.S1128I	ACH-000787	Lung Cancer	CCLE	DSGGSSS	DEG_SCF_TRCP1_1	0.8453
p.S1128I	LXF-289	lung	COSMIC	DSGGSSS	DEG_SCF_TRCP1_1	0.8453

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_SCF_TRCP1_1	760:766	DSGGSSS	BTRC	0.9953	More...
Q96KG7	Multiple epidermal growth factor-like domains protein 10	DEG_SCF_TRCP1_1	1127:1133	DSGGSSS	BTRC	0.9746	More...
Q969W3	Protein FAM104A	DEG_SCF_TRCP1_1	112:118	DSGGSSS	BTRC	0.9611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons