DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LQHRGR
Uniprot ID:
Q969W3
Source protein:
Protein FAM104A
Source gene:
FAM104A
Class:
SCF_FBXL2
Location:
178:183
E3 ligase:
FBXL2
DEGRON score:
0.7102
ASA_SCORE:
97.9667
COIL:
0.6243
CONS_SCORE:
0.9517
DSS_SCORE:
0.6692
HELIX:
0.3673
FCONS_SCORE:
1.0318
RIG_SCORE:
0.6909
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E175K
TCGA-AX-A2HC
UCEC
TCGA
LQHRGR
SCF_FBXL2
0.25
Drug responses associated with FAM104A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQHRGR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q969W3
Protein FAM104A
SCF_FBXL2
178:183
LQHRGR
FBXL2
0.7102
More...