DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_SCF_FBW7_1

Location: 1543:1550

E3 ligase: FBXW7

DEGRON score: 0.9736

ASA_SCORE: 85.125

COIL: 0.9391

CONS_SCORE: 0.4514

DSS_SCORE: 0.7243

HELIX: 0.0376

FCONS_SCORE: 0.9781

RIG_SCORE: 0.5463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1552E	TCGA-2H-A9GO	ESCA	TCGA	VGGTPRDS	DEG_SCF_FBW7_1	0.2778
p.A1551S	TCGA-69-7978	LUAD	TCGA	VGGTPRDS	DEG_SCF_FBW7_1	0.3056
p.A1551S	DO24920	LUAD	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	0.3056
p.R1560C	TCGA-B5-A3FC	UCEC	TCGA	VGGTPRDS	DEG_SCF_FBW7_1	0.0556
p.R1560C	DO41871	UCEC	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	0.0556
p.G1552R	DO50329	ESAD	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	0.2778
p.R1548W	DO233737	GACA	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	0.7523
p.P1558S	DO220878	MELA	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	0.1111
p.PP1557PS	DO220878	MELA	ICGC	VGGTPRDS	DEG_SCF_FBW7_1	0
p.P1557T	SIDM01578	Bladder Carcinoma	GDSC	VGGTPRDS	DEG_SCF_FBW7_1	0.1389
p.P1557T	ACH-000862	Bladder Cancer	CCLE	VGGTPRDS	DEG_SCF_FBW7_1	0.1389
p.V1543L	ACH-000710	Lung Cancer	CCLE	VGGTPRDS	DEG_SCF_FBW7_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_SCF_FBW7_1	1543:1550	VGGTPRDS	FBXW7	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons