DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_SCF_TRCP1_1

Location: 1650:1656

E3 ligase: BTRC

DEGRON score: 0.9787

ASA_SCORE: 78.1714

COIL: 0.9126

CONS_SCORE: 0.5878

DSS_SCORE: 0.7238

HELIX: 0.0509

FCONS_SCORE: 0.9986

RIG_SCORE: 0.6328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1645Q	TCGA-GV-A3JX	BLCA	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.1944
p.E1645Q	DO448	BLCA	ICGC	DSGVDLS	DEG_SCF_TRCP1_1	0.1944
p.G1664D	DO232761	PBCA	ICGC	DSGVDLS	DEG_SCF_TRCP1_1	0.1111
p.S1651G	DO229181	THCA	ICGC	DSGVDLS	DEG_SCF_TRCP1_1	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons