DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_SCF_TRCP1_1

Location: 1670:1676

E3 ligase: BTRC

DEGRON score: 0.9995

ASA_SCORE: 75.5

COIL: 0.8317

CONS_SCORE: 1

DSS_SCORE: 0.6435

HELIX: 0.1203

FCONS_SCORE: 1.064

RIG_SCORE: 0.6307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1679Y	TCGA-5C-A9VG	LIHC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.6944
p.E1678K	TCGA-AP-A056	UCEC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.2778
p.R1680Q	TCGA-BR-4362	STAD	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.2222
p.R1680Q	TCGA-BR-6566	STAD	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.2222
p.R1680Q	TCGA-GS-A9TU	DLBC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.2222
p.E1678D	TCGA-BR-7851	STAD	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.2778
p.S1676I	TCGA-RC-A6M3	LIHC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	0.8453
p.S1683P	SIDM00781	Colorectal Carcinoma	GDSC	DSGVDLS	DEG_SCF_TRCP1_1	0.1389
p.S1683P	SIDM00780	Colorectal Carcinoma	GDSC	DSGVDLS	DEG_SCF_TRCP1_1	0.1389
p.S1683P	SNU-C2B	large_intestine	COSMIC	DSGVDLS	DEG_SCF_TRCP1_1	0.1389
p.E1681G	SIDM01045	Endometrial Carcinoma	GDSC	DSGVDLS	DEG_SCF_TRCP1_1	0.1944
p.E1681G	EN	endometrium	COSMIC	DSGVDLS	DEG_SCF_TRCP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons