DegronMD - Q5JSZ5(PRRC2B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V692L	TCGA-06-5416	GBM	TCGA	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.2778
p.V692L	DO10880	GBM	ICGC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.2778
p.S288L	TCGA-09-2043	OV	TCGA	PPTY	ITCH	275:278	Mutation blocking phosphorylation signal	0.5
p.S288L	DO29750	OV	ICGC	PPTY	ITCH	275:278	Mutation blocking phosphorylation signal	0.5
p.Q318H	TCGA-17-Z055	LUAD	TCGA	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1111
p.S1898F	TCGA-3N-A9WD	SKCM	TCGA	MPVASVAPS	DEG_SIAH_1	1907:1915	Mutation rewiring degron network	0.0833
p.Q93L	TCGA-52-7809	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.Q93L	DO26746	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.A698S	TCGA-55-8301	LUAD	TCGA	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.1111
p.A698S	DO24682	LUAD	ICGC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.1111
p.S1679Y	TCGA-5C-A9VG	LIHC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation blocking phosphorylation signal	0.6944
p.A54D	TCGA-61-2008	OV	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1944
p.A54D	DO29658	OV	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1944
p.Q928H	TCGA-A5-A1OF	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.2778
p.Q928H	DO42568	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.2778
p.A34T	TCGA-A6-6781	COAD	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	TCGA-AG-A002	READ	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	TCGA-AP-A1DO	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	TCGA-B5-A3FA	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	DO8447	COAD	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	DO43250	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	DO52402	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	SIDM00217	Colorectal Carcinoma	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	ACH-000999	Colon/Colorectal Cancer	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34T	SNU-1040	large intestine	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.Y273C	TCGA-AA-3673	COAD	TCGA	PPTY	ITCH	275:278	Mutation rewiring degron network	0.2778
p.Y273C	DO10419	COAD	ICGC	PPTY	ITCH	275:278	Mutation rewiring degron network	0.2778
p.R55W	TCGA-AA-3864	COAD	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1667
p.R55W	DO8490	COAD	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1667
p.R55W	ACH-001518	Endometrial/Uterine Cancer	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1667
p.G270E	TCGA-AG-A002	READ	TCGA	PPTY	ITCH	275:278	Mutation rewiring degron network	0.1944
p.D95Y	TCGA-AO-A0J4	BRCA	TCGA	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.D95Y	DO1559	BRCA	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.E1678K	TCGA-AP-A056	UCEC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.2778
p.D92N	TCGA-AP-A059	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2222
p.D92N	DO41361	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2222
p.G326R	TCGA-AX-A1CE	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation altering degron motif	0.6457
p.G326R	DO42280	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation altering degron motif	0.6457
p.G326R	SIDM00217	Colorectal Carcinoma	GDSC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation altering degron motif	0.6457
p.G326R	SNU-1040	large intestine	COSMIC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation altering degron motif	0.6457
p.S109L	TCGA-AX-A2HC	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0833
p.S109L	DO41572	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0833
p.R684H	TCGA-B5-A3FC	UCEC	TCGA	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.7133
p.R684H	DO41871	UCEC	ICGC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.7133
p.R684H	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.7133
p.R684H	ACH-000914	Lymphoma	CCLE	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.7133
p.R684H	HT	haematopoietic and lymphoid tissue	COSMIC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.7133
p.A34G	TCGA-B6-A0I1	BRCA	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A34G	DO4138	BRCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.P96Q	TCGA-BF-A1PZ	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7035
p.P96Q	DO50279	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7035
p.R1680Q	TCGA-BR-4362	STAD	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.2222
p.R1680Q	TCGA-BR-6566	STAD	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.2222
p.R1680Q	TCGA-GS-A9TU	DLBC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.2222
p.E1678D	TCGA-BR-7851	STAD	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.2778
p.T686M	TCGA-CG-5726	STAD	TCGA	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.8534
p.T686M	TCGA-KK-A59V	PRAD	TCGA	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.8534
p.T686M	DO51346	PRAD	ICGC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.8534
p.T686M	DO38483	STAD	ICGC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.8534
p.H929N	TCGA-CM-5864	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.25
p.H929N	DO8690	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.25
p.W918L	TCGA-CR-7402	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.2222
p.R56C	TCGA-CX-7219	HNSC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.R56C	DO14910	HNSC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.P107L	TCGA-D5-6928	COAD	TCGA	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.P107L	DO7776	COAD	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.M269T	TCGA-D8-A1XK	BRCA	TCGA	PPTY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.M269T	DO4749	BRCA	ICGC	PPTY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.S37P	TCGA-DI-A1C3	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2222
p.S37P	DO43803	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2222
p.H700Y	TCGA-DK-AA76	BLCA	TCGA	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.0556
p.H700Y	DO219013	BLCA	ICGC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.0556
p.R42I	TCGA-E6-A1LX	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8102
p.R42I	DO41020	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8102
p.Y273D	TCGA-EO-A22X	UCEC	TCGA	PPTY	ITCH	275:278	Mutation rewiring degron network	0.2778
p.Y273D	DO43907	UCEC	ICGC	PPTY	ITCH	275:278	Mutation rewiring degron network	0.2778
p.R338C	TCGA-EO-A3AU	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1111
p.R338C	DO43827	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1111
p.R338C	SIDM00614	Hepatocellular Carcinoma	GDSC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1111
p.R338C	ACH-000848	Liver Cancer	CCLE	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1111
p.R338C	JHH-7	liver	COSMIC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1111
p.M269I	TCGA-FS-A1ZB	SKCM	TCGA	PPTY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.M269I	DO37886	SKCM	ICGC	PPTY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.P742H	TCGA-G4-6588	COAD	TCGA	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2778
p.P742H	DO10140	COAD	ICGC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2778
p.P742H	SIDM01951	Colorectal Carcinoma	GDSC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2778
p.A52T	TCGA-GC-A3RC	BLCA	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.A52T	DO816	BLCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.R317I	TCGA-IN-A6RL	STAD	TCGA	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.0833
p.R317I	DO51738	STAD	ICGC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.0833
p.C726R	TCGA-LC-A66R	BLCA	TCGA	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.0833
p.C726R	DO44031	BLCA	ICGC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.0833
p.I738F	TCGA-NC-A5HP	LUSC	TCGA	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation altering degron motif	0.6304
p.I738F	DO219199	LUSC	ICGC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation altering degron motif	0.6304
p.R733T	TCGA-Q1-A73O	CESC	TCGA	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2778
p.R733T	DO51612	CESC	ICGC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2778
p.S1676I	TCGA-RC-A6M3	LIHC	TCGA	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation altering degron motif	0.8453
p.Q105E	TCGA-VS-A8EI	CESC	TCGA	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1944
p.Q105E	DO51621	CESC	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1944
p.R335H	TCGA-XR-A8TC	LIHC	TCGA	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1944
p.R335H	DO223920	LIHC	ICGC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1944
p.S104Y	DO225087	BRCA	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2222
p.P59L	DO222973	BTCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.P59L	SIDM02013	Colorectal Carcinoma	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.P729S	DO229341	BTCA	ICGC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.1667
p.F268V	DO227549	COCA	ICGC	PPTY	ITCH	275:278	Mutation rewiring degron network	0.1389
p.P106L	DO222755	COCA	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1667
p.R56H	DO222762	COCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.R56H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.R56H	ACH-001127	Leukemia	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.R56H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.T936S	DO229010	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation blocking phosphorylation signal	0.5
p.T936S	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation blocking phosphorylation signal	0.5
p.T936S	DO229016	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation blocking phosphorylation signal	0.5
p.T936S	DO229003	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation blocking phosphorylation signal	0.5
p.T936S	DO229005	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation blocking phosphorylation signal	0.5
p.D323N	DO234467	ESAD	ICGC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.25
p.L333S	DO233869	GACA	ICGC	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.25
p.Q912R	DO18651	KIRC	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.0556
p.S100I	DO229018	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7341
p.Q91H	DO229029	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1944
p.E108G	DO229039	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1111
p.G86E	DO27855	MALY	ICGC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.T923I	DO37583	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation altering degron motif	0.7078
p.V924M	DO47819	STAD	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation altering degron motif	0.7208
p.V924M	DO42673	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation altering degron motif	0.7208
p.P925H	DO229216	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation altering degron motif	0.7694
p.V922M	DO229234	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation altering degron motif	0.7208
p.G930D	DO50076	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.2222
p.T102M	SIDM01137	Pancreatic Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.T102M	ACH-000235	Pancreatic Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.T102M	PANC-04-03	pancreas	COSMIC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.A1651V	SIDM00798	Rhabdomyosarcoma	GDSC	AFSST	DEG_SPOP_SBC_1	1651:1655	Mutation altering degron motif	0.5825
p.A1651V	SIDM00627	Cervical Carcinoma	GDSC	AFSST	DEG_SPOP_SBC_1	1651:1655	Mutation altering degron motif	0.5825
p.A1651V	SIDM00337	Melanoma	GDSC	AFSST	DEG_SPOP_SBC_1	1651:1655	Mutation altering degron motif	0.5825
p.A1651V	SIDM01186	Breast Carcinoma	GDSC	AFSST	DEG_SPOP_SBC_1	1651:1655	Mutation altering degron motif	0.5825
p.A1651V	SIDM00461	Acute Myeloid Leukemia	GDSC	AFSST	DEG_SPOP_SBC_1	1651:1655	Mutation altering degron motif	0.5825
p.A1651V	SIDM00059	Ovarian Carcinoma	GDSC	AFSST	DEG_SPOP_SBC_1	1651:1655	Mutation altering degron motif	0.5825
p.L110Q	SIDM00845	Burkitt's Lymphoma	GDSC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.L110Q	SIDM00035	Thyroid Gland Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.L110Q	SIDM00461	Acute Myeloid Leukemia	GDSC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.L110Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.L110Q	SIDM01519	Head and Neck Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.L110Q	ACH-000037	Sarcoma	CCLE	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.L110Q	ACH-000786	Lymphoma	CCLE	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.L110Q	ACH-001067	Brain Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.P930L	SIDM01090	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	922:926	Mutation rewiring degron network	0.2222
p.W744R	SIDM00258	Neuroblastoma	GDSC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2222
p.W744R	SIDM00564	Ovarian Carcinoma	GDSC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2222
p.S1683P	SIDM00781	Colorectal Carcinoma	GDSC	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.1389
p.S1683P	SIDM00780	Colorectal Carcinoma	GDSC	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.1389
p.S1683P	SNU-C2B	large intestine	COSMIC	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.1389
p.A1910T	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	MPVASVAPS	DEG_SIAH_1	1907:1915	Mutation altering degron motif	0.7139
p.A1910T	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	MPVASVAPS	DEG_SIAH_1	1907:1915	Mutation altering degron motif	0.7139
p.P1924S	SIDM01039	Other Solid Cancers	GDSC	PPLY	ITCH	1924:1927	Mutation altering degron motif	0.6752
p.A52V	SIDM01113	Other Sarcomas	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.A52V	ACH-000939	Sarcoma	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.A52V	SK-UT-1	soft tissue	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.E1681G	SIDM01045	Endometrial Carcinoma	GDSC	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.1944
p.E1681G	EN	endometrium	COSMIC	DSGVDLS	DEG_SCF_TRCP1_1	1670:1676	Mutation rewiring degron network	0.1944
p.P737S	SIDM00853	Other Sarcomas	GDSC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation altering degron motif	0.6752
p.P737S	ACH-000835	Sarcoma	CCLE	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation altering degron motif	0.6752
p.P737S	GCT	soft tissue	COSMIC	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation altering degron motif	0.6752
p.A698T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.1111
p.A698T	ACH-000980	Lung Cancer	CCLE	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.1111
p.A698T	NCI-H1155	lung	COSMIC	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation rewiring degron network	0.1111
p.R733I	ACH-000306	Non-Cancerous	CCLE	VTPIDS	DEG_SCF_FBW7_1	735:740	Mutation rewiring degron network	0.2778
p.R689G	ACH-001536	Bile Duct Cancer	CCLE	PRITPTRT	DEG_SCF_FBW7_1	683:690	Mutation altering degron motif	0.6457
p.R338H	ACH-001719	Ovarian Cancer	CCLE	GKENR	DEG_APCC_KENBOX_2	326:330	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRC2B

UniProt ID: Q5JSZ5

Entrez ID: 84726

Protein name: Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PRRC2B in