DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_APCC_DBOX_1

Location: 41:49

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9877

ASA_SCORE: 83.1556

COIL: 0.823

CONS_SCORE: 0.6685

DSS_SCORE: 0.4097

HELIX: 0.0323

FCONS_SCORE: 1.106

RIG_SCORE: 0.7133

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A54D	TCGA-61-2008	OV	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1944
p.A54D	DO29658	OV	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1944
p.A34T	TCGA-A6-6781	COAD	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	TCGA-AG-A002	READ	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	TCGA-AP-A1DO	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	TCGA-B5-A3FA	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	DO8447	COAD	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	DO43250	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	DO52402	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	SIDM00217	Colorectal Carcinoma	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	ACH-000999	Colon/Colorectal Cancer	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34T	SNU-1040	large_intestine	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R55W	TCGA-AA-3864	COAD	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.R55W	DO8490	COAD	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.R55W	ACH-001518	Endometrial/Uterine Cancer	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.A34G	TCGA-B6-A0I1	BRCA	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A34G	DO4138	BRCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R56C	TCGA-CX-7219	HNSC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R56C	DO14910	HNSC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.S37P	TCGA-DI-A1C3	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.2222
p.S37P	DO43803	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.2222
p.R42I	TCGA-E6-A1LX	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.8102
p.R42I	DO41020	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.8102
p.A52T	TCGA-GC-A3RC	BLCA	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.25
p.A52T	DO816	BLCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.25
p.P59L	DO222973	BTCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.0556
p.P59L	SIDM02013	Colorectal Carcinoma	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	0.0556
p.R56H	DO222762	COCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R56H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R56H	ACH-001127	Leukemia	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R56H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.A52V	SIDM01113	Other Sarcomas	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	0.25
p.A52V	ACH-000939	Sarcoma	CCLE	PRHGLQSLG	DEG_APCC_DBOX_1	0.25
p.A52V	SK-UT-1	soft_tissue	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_APCC_DBOX_1	40:48	PRHGLQSLG	APC,CDC20,FZR1	0.7976	More...
Q5JSZ5	Protein PRRC2B	DEG_APCC_DBOX_1	41:49	PRHGLQSLG	APC,CDC20,FZR1	0.9877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRHGLQSLG

Degron related mutations and impact score

Drug responses associated with PRRC2B mutations

All proteins holding degron of PRHGLQSLG