DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_APCC_DBOX_1

Location: 40:48

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7976

ASA_SCORE: 91.0333

COIL: 0.9066

CONS_SCORE: 0.9616

DSS_SCORE: 0.4346

HELIX: 0.0378

FCONS_SCORE: 1.0856

RIG_SCORE: 0.709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K49N	TCGA-AP-A051	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.3056
p.K49N	DO42673	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.3056
p.R55H	TCGA-AP-A0LM	UCEC	TCGA	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R55H	DO43306	UCEC	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1389
p.R54W	DO223074	ESCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1667
p.P57S	DO233058	GACA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.0833
p.E32K	DO32831	PACA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.1111
p.Q45R	DO229199	THCA	ICGC	PRHGLQSLG	DEG_APCC_DBOX_1	0.6218
p.A37T	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PRHGLQSLG	DEG_APCC_DBOX_1	0.25
p.A37T	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PRHGLQSLG	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons