DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_SIAH_1

Location: 1907:1915

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9445

ASA_SCORE: 82.9667

COIL: 0.9237

CONS_SCORE: 0.9636

DSS_SCORE: 0.3855

HELIX: 0.0234

FCONS_SCORE: 1.0077

RIG_SCORE: 0.6856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1898F	TCGA-3N-A9WD	SKCM	TCGA	MPVASVAPS	DEG_SIAH_1	0.0833
p.A1910T	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	MPVASVAPS	DEG_SIAH_1	0.7139
p.A1910T	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	MPVASVAPS	DEG_SIAH_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSZ5	Protein PRRC2B	DEG_SIAH_1	1907:1915	MPVASVAPS	SIAH1,SIAH2,SIAH3	0.9445	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons