DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_SPOP_SBC_1

Location: 1651:1655

E3 ligase: SPOP

DEGRON score: 0.9809

ASA_SCORE: 83.6

COIL: 0.848

CONS_SCORE: 0.8569

DSS_SCORE: 0.4917

HELIX: 0.119

FCONS_SCORE: 1.0624

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1651V	SIDM00798	Rhabdomyosarcoma	GDSC	AFSST	DEG_SPOP_SBC_1	0.5825
p.A1651V	SIDM00627	Cervical Carcinoma	GDSC	AFSST	DEG_SPOP_SBC_1	0.5825
p.A1651V	SIDM00337	Melanoma	GDSC	AFSST	DEG_SPOP_SBC_1	0.5825
p.A1651V	SIDM01186	Breast Carcinoma	GDSC	AFSST	DEG_SPOP_SBC_1	0.5825
p.A1651V	SIDM00461	Acute Myeloid Leukemia	GDSC	AFSST	DEG_SPOP_SBC_1	0.5825
p.A1651V	SIDM00059	Ovarian Carcinoma	GDSC	AFSST	DEG_SPOP_SBC_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons