DegronMD

Uniprot ID: Q8IYX0

Source protein: Zinc finger protein 679

Source gene: ZNF679

Class: DEG_SPOP_SBC_1

Location: 362:366

E3 ligase: SPOP

DEGRON score: 0.585

ASA_SCORE: 63.6

COIL: 0.667

CONS_SCORE: 0.6588

DSS_SCORE: 0.1407

HELIX: 0.0506

FCONS_SCORE: 0.7624

RIG_SCORE: 0.7719

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A360V	TCGA-A5-A0G2	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.2778
p.A360V	DO41235	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.2778
p.L367I	TCGA-A5-A1OF	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.3056
p.L367I	DO42568	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.3056
p.F363L	TCGA-AP-A0LM	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.587
p.F363L	TCGA-B5-A0JY	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.587
p.F363L	TCGA-B5-A1MR	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.587
p.F363L	DO43306	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.587
p.F363L	DO43041	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.587
p.F363L	DO41758	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.587
p.K371T	TCGA-AP-A1DV	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.3056
p.K371T	DO43186	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.3056
p.Y352F	TCGA-AZ-5407	COAD	TCGA	AFSST	DEG_SPOP_SBC_1	0.0556
p.Y352F	DO8432	COAD	ICGC	AFSST	DEG_SPOP_SBC_1	0.0556
p.T375N	TCGA-B5-A11E	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.5278
p.T375N	DO41644	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.5278
p.T366N	TCGA-B5-A11N	UCEC	TCGA	AFSST	DEG_SPOP_SBC_1	0.7055
p.T366N	DO41458	UCEC	ICGC	AFSST	DEG_SPOP_SBC_1	0.7055
p.H370Y	TCGA-D3-A8GB	SKCM	TCGA	AFSST	DEG_SPOP_SBC_1	0.2222
p.H370Y	DO50280	SKCM	ICGC	AFSST	DEG_SPOP_SBC_1	0.2222
p.S364P	TCGA-DD-AADI	LIHC	TCGA	AFSST	DEG_SPOP_SBC_1	0.6752
p.S364P	DO52233	LIHC	ICGC	AFSST	DEG_SPOP_SBC_1	0.6752
p.E356V	TCGA-EE-A182	SKCM	TCGA	AFSST	DEG_SPOP_SBC_1	0.1667
p.E356V	DO37814	SKCM	ICGC	AFSST	DEG_SPOP_SBC_1	0.1667
p.K355E	TCGA-EL-A3ZN	THCA	TCGA	AFSST	DEG_SPOP_SBC_1	0.25
p.K355E	DO51458	THCA	ICGC	AFSST	DEG_SPOP_SBC_1	0.25
p.A360D	TCGA-IB-7651	PAAD	TCGA	AFSST	DEG_SPOP_SBC_1	0.2778
p.A360D	DO46657	PAAD	ICGC	AFSST	DEG_SPOP_SBC_1	0.2778
p.C354F	TCGA-MP-A4TF	LUAD	TCGA	AFSST	DEG_SPOP_SBC_1	0.1111
p.C354F	DO45316	LUAD	ICGC	AFSST	DEG_SPOP_SBC_1	0.1111
p.T366A	TCGA-NC-A5HM	LUSC	TCGA	AFSST	DEG_SPOP_SBC_1	0.7139
p.T366A	DO219195	LUSC	ICGC	AFSST	DEG_SPOP_SBC_1	0.7139
p.K371N	DO224732	BRCA	ICGC	AFSST	DEG_SPOP_SBC_1	0.3056
p.K371N	ACH-001389	Breast Cancer	CCLE	AFSST	DEG_SPOP_SBC_1	0.3056
p.F361L	DO222762	COCA	ICGC	AFSST	DEG_SPOP_SBC_1	0.3056
p.E356G	DO222798	COCA	ICGC	AFSST	DEG_SPOP_SBC_1	0.1667
p.G358W	DO50974	LICA	ICGC	AFSST	DEG_SPOP_SBC_1	0.2222
p.C354S	DO23702	LUAD	ICGC	AFSST	DEG_SPOP_SBC_1	0.1111
p.Y352S	DO231104	LUSC	ICGC	AFSST	DEG_SPOP_SBC_1	0.0556
p.E356K	DO220862	MELA	ICGC	AFSST	DEG_SPOP_SBC_1	0.1667
p.R372K	DO222662	MELA	ICGC	AFSST	DEG_SPOP_SBC_1	0.1667
p.T366I	SIDM00485	Oral Cavity Carcinoma	GDSC	AFSST	DEG_SPOP_SBC_1	0.7078
p.T366I	ACH-000794	Head and Neck Cancer	CCLE	AFSST	DEG_SPOP_SBC_1	0.7078
p.T366I	BICR22	upper_aerodigestive_tract	COSMIC	AFSST	DEG_SPOP_SBC_1	0.7078
p.S365L	SIDM01694	B-Lymphoblastic Leukemia	GDSC	AFSST	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	1651:1655	AFSST	SPOP	0.9809	More...
Q8IYX0	Zinc finger protein 679	DEG_SPOP_SBC_1	362:366	AFSST	SPOP	0.585	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AFSST

Degron related mutations and impact score

Drug responses associated with ZNF679 mutations

All proteins holding degron of AFSST