DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_SCF_FBW7_1

Location: 683:690

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 105.875

COIL: 0.9633

CONS_SCORE: 0.9575

DSS_SCORE: 0.3666

HELIX: 0.0238

FCONS_SCORE: 0.9575

RIG_SCORE: 0.7069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V692L	TCGA-06-5416	GBM	TCGA	PRITPTRT	DEG_SCF_FBW7_1	0.2778
p.V692L	DO10880	GBM	ICGC	PRITPTRT	DEG_SCF_FBW7_1	0.2778
p.A698S	TCGA-55-8301	LUAD	TCGA	PRITPTRT	DEG_SCF_FBW7_1	0.1111
p.A698S	DO24682	LUAD	ICGC	PRITPTRT	DEG_SCF_FBW7_1	0.1111
p.R684H	TCGA-B5-A3FC	UCEC	TCGA	PRITPTRT	DEG_SCF_FBW7_1	0.7133
p.R684H	DO41871	UCEC	ICGC	PRITPTRT	DEG_SCF_FBW7_1	0.7133
p.R684H	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRITPTRT	DEG_SCF_FBW7_1	0.7133
p.R684H	ACH-000914	Lymphoma	CCLE	PRITPTRT	DEG_SCF_FBW7_1	0.7133
p.R684H	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PRITPTRT	DEG_SCF_FBW7_1	0.7133
p.T686M	TCGA-CG-5726	STAD	TCGA	PRITPTRT	DEG_SCF_FBW7_1	0.8534
p.T686M	TCGA-KK-A59V	PRAD	TCGA	PRITPTRT	DEG_SCF_FBW7_1	0.8534
p.T686M	DO51346	PRAD	ICGC	PRITPTRT	DEG_SCF_FBW7_1	0.8534
p.T686M	DO38483	STAD	ICGC	PRITPTRT	DEG_SCF_FBW7_1	0.8534
p.H700Y	TCGA-DK-AA76	BLCA	TCGA	PRITPTRT	DEG_SCF_FBW7_1	0.0556
p.H700Y	DO219013	BLCA	ICGC	PRITPTRT	DEG_SCF_FBW7_1	0.0556
p.A698T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRITPTRT	DEG_SCF_FBW7_1	0.1111
p.A698T	ACH-000980	Lung Cancer	CCLE	PRITPTRT	DEG_SCF_FBW7_1	0.1111
p.A698T	NCI-H1155	lung	COSMIC	PRITPTRT	DEG_SCF_FBW7_1	0.1111
p.R689G	ACH-001536	Bile Duct Cancer	CCLE	PRITPTRT	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSZ5	Protein PRRC2B	DEG_SCF_FBW7_1	683:690	PRITPTRT	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons