DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_SPOP_SBC_1

Location: 96:100

E3 ligase: SPOP

DEGRON score: 0.8516

ASA_SCORE: 94.42

COIL: 0.8444

CONS_SCORE: 0.6521

DSS_SCORE: 0.8377

HELIX: 0.1398

FCONS_SCORE: 1.0455

RIG_SCORE: 0.5691

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S100I	DO229018	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7341
p.P96Q	TCGA-BF-A1PZ	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.7035
p.P96Q	DO50279	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7035
p.D95Y	TCGA-AO-A0J4	BRCA	TCGA	PKSSS	DEG_SPOP_SBC_1	0.3056
p.D95Y	DO1559	BRCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.3056
p.T102M	SIDM01137	Pancreatic Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.T102M	ACH-000235	Pancreatic Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.2778
p.T102M	PANC-04-03	pancreas	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.Q93L	TCGA-52-7809	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.25
p.Q93L	DO26746	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.D92N	TCGA-AP-A059	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.2222
p.D92N	DO41361	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2222
p.S104Y	DO225087	BRCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2222
p.Q105E	TCGA-VS-A8EI	CESC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1944
p.Q105E	DO51621	CESC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.Q91H	DO229029	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.P106L	DO222755	COCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.P107L	TCGA-D5-6928	COAD	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1389
p.P107L	DO7776	COAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1389
p.E108G	DO229039	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1111
p.S109L	TCGA-AX-A2HC	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.0833
p.S109L	DO41572	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833
p.G86E	DO27855	MALY	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.L110Q	SIDM00845	Burkitt's Lymphoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.L110Q	SIDM00035	Thyroid Gland Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 31 entries

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Drug responses associated with PRRC2B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PKSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...

Showing 1 to 22 of 22 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with PRRC2B mutations

All proteins holding degron of PKSSS