DegronMD - Q9BX69(CARD6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D31G	TCGA-AB-2807	LAML	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0833
p.D31G	DO21589	LAML	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0833
p.S1005Y	TCGA-AX-A05Z	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.1389
p.S1005Y	DO40884	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.1389
p.E20D	TCGA-CA-6717	COAD	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.5647
p.E20D	DO8264	COAD	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.5647
p.S1005C	TCGA-D6-A6EO	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.1389
p.S1005C	DO52083	HNSC	ICGC	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.1389
p.L22I	TCGA-DF-A2KN	UCEC	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6063
p.L22I	DO223282	UCEC	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6063
p.E9G	TCGA-DF-A2KU	UCEC	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1944
p.E9G	DO223286	UCEC	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1944
p.T6A	TCGA-G4-6588	COAD	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.T6A	DO10140	COAD	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.S28F	TCGA-KQ-A41R	BLCA	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation blocking phosphorylation signal	0.6111
p.S28F	TCGA-YC-A89H	BLCA	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation blocking phosphorylation signal	0.6111
p.S28F	DO51948	BLCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation blocking phosphorylation signal	0.6111
p.S28F	DO223592	BLCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation blocking phosphorylation signal	0.6111
p.I10M	TCGA-OR-A5KB	ACC	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.E14K	TCGA-YC-A89H	BLCA	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.591
p.E14K	DO51948	BLCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.591
p.R15K	DO229177	LMS	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7237
p.S1005F	DO222402	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.1389
p.P7L	DO219873	SKCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1389
p.P1019L	SIDM00987	Thyroid Gland Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.25
p.P1019L	ACH-000191	Thyroid Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.25
p.P1019L	BHT-101	thyroid	COSMIC	PKSSS	DEG_SPOP_SBC_1	1012:1016	Mutation rewiring degron network	0.25
p.L30S	SIDM00057	Neuroblastoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30S	SIDM00710	Small Cell Lung Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30S	SIDM00982	Glioblastoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.R13S	SIDM00683	Prostate Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.3056
p.R13S	LNCaP-Clone-FGC	prostate	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.3056
p.I10V	SIDM00807	Bladder Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.L30I	WM35	skin	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30I	NCI-H596	lung	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30I	LB771-HNC	upper aerodigestive tract	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30I	BCPAP	thyroid	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30I	NCI-H2081	lung	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.L30I	VMRC-LCD	lung	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CARD6

UniProt ID: Q9BX69

Entrez ID: 84674

Protein name: Caspase recruitment domain-containing protein 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CARD6 in