DegronMD

Uniprot ID: Q9BX69

Source protein: Caspase recruitment domain-containing protein 6

Source gene: CARD6

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6936

ASA_SCORE: 58.1889

COIL: 0.0283

CONS_SCORE: 0.8269

DSS_SCORE: 0.394

HELIX: 0.9702

FCONS_SCORE: 0.9928

RIG_SCORE: 0.7966

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D31G	TCGA-AB-2807	LAML	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.0833
p.D31G	DO21589	LAML	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.0833
p.E20D	TCGA-CA-6717	COAD	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.5647
p.E20D	DO8264	COAD	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.5647
p.L22I	TCGA-DF-A2KN	UCEC	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.6063
p.L22I	DO223282	UCEC	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.6063
p.E9G	TCGA-DF-A2KU	UCEC	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.1944
p.E9G	DO223286	UCEC	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1944
p.T6A	TCGA-G4-6588	COAD	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.T6A	DO10140	COAD	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.S28F	TCGA-KQ-A41R	BLCA	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.6111
p.S28F	TCGA-YC-A89H	BLCA	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.6111
p.S28F	DO51948	BLCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.6111
p.S28F	DO223592	BLCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.6111
p.I10M	TCGA-OR-A5KB	ACC	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.2222
p.E14K	TCGA-YC-A89H	BLCA	TCGA	ERKKLLEIL	DEG_APCC_DBOX_1	0.591
p.E14K	DO51948	BLCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.591
p.R15K	DO229177	LMS	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.7237
p.P7L	DO219873	SKCA	ICGC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1389
p.L30S	SIDM00057	Neuroblastoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30S	SIDM00710	Small Cell Lung Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30S	SIDM00982	Glioblastoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.R13S	SIDM00683	Prostate Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	0.3056
p.R13S	LNCaP-Clone-FGC	prostate	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	0.3056
p.I10V	SIDM00807	Bladder Carcinoma	GDSC	ERKKLLEIL	DEG_APCC_DBOX_1	0.2222
p.L30I	WM35	skin	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30I	NCI-H596	lung	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30I	LB771-HNC	upper_aerodigestive_tract	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30I	BCPAP	thyroid	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30I	NCI-H2081	lung	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111
p.L30I	VMRC-LCD	lung	COSMIC	ERKKLLEIL	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERKKLLEIL

Degron related mutations and impact score

Drug responses associated with CARD6 mutations

All proteins holding degron of ERKKLLEIL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_APCC_DBOX_1	14:22	ERKKLLEIL	APC,CDC20,FZR1	0.6936	More...