DegronMD

Uniprot ID: Q6DN12

Source protein: Multiple C2 and transmembrane domain-containing protein 2

Source gene: MCTP2

Class: DEG_SPOP_SBC_1

Location: 89:93

E3 ligase: SPOP

DEGRON score: 0.7468

ASA_SCORE: 85.3

COIL: 0.885

CONS_SCORE: 0.3589

DSS_SCORE: 0.5322

HELIX: 0.0706

FCONS_SCORE: 0.9933

RIG_SCORE: 0.6382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T84A	TCGA-BJ-A4O8	THCA	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1944
p.T84A	DO48066	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.G86E	TCGA-EE-A29D	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.25
p.G86E	DO38123	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.S91R	TCGA-EP-A2KC	LIHC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.7427
p.S91R	DO22966	LIHC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7427
p.R83Q	DO223586	CLLE	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.R83Q	DO37814	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.G97S	DO10212	COAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.3333
p.G97S	DO9876	COAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.3333
p.G97S	DO42713	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.3333
p.V93L	DO229034	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6765
p.V101M	DO52318	LIHC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1111
p.V96F	DO26790	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.P89S	DO220894	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6752
p.P89S	DO220912	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6752
p.L82V	DO229066	PRAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1389
p.L90P	DO51795	STAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7582
p.S93N	SIDM00600	Thyroid Gland Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.7069
p.S93N	ACH-001528	Thyroid Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.7069
p.S93N	IHH-4	thyroid	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.7069
p.S80R	SIDM00538	Esophageal Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.5278
p.S80R	ESO51	oesophagus	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.5278
p.P79H	SIDM00585	Hepatocellular Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.P79H	ACH-000480	Liver Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.0556
p.P79H	HuH-7	liver	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.S81N	SIDM00387	Neuroblastoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.1111
p.S81N	MHH-NB-11	autonomic_ganglia	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with MCTP2 mutations

All proteins holding degron of PKSSS