DegronMD - Q5T200(ZC3H13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P225R	TCGA-17-Z057	LUAD	TCGA	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7512
p.T237A	TCGA-19-5956	GBM	TCGA	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation blocking phosphorylation signal	0.5556
p.T237A	DO13863	GBM	ICGC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation blocking phosphorylation signal	0.5556
p.P1035S	TCGA-24-1564	OV	TCGA	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation altering degron motif	0.5641
p.P1035S	DO28022	OV	ICGC	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation altering degron motif	0.5641
p.I327V	TCGA-33-4566	LUSC	TCGA	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.I327V	DO26790	LUSC	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.S218C	TCGA-44-5644	LUAD	TCGA	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation blocking phosphorylation signal	0.5833
p.S218C	DO25153	LUAD	ICGC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation blocking phosphorylation signal	0.5833
p.A239V	TCGA-AA-3815	COAD	TCGA	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.A239V	DO9924	COAD	ICGC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.R1158K	TCGA-AP-A0LM	UCEC	TCGA	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.0556
p.R1158K	DO43306	UCEC	ICGC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.0556
p.K233E	TCGA-AP-A0LM	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation substituting flanking lysine	0.3333
p.K233E	DO43306	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation substituting flanking lysine	0.3333
p.S325F	TCGA-B5-A11E	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation blocking phosphorylation signal	0.5833
p.S325F	DO41644	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation blocking phosphorylation signal	0.5833
p.E305Q	TCGA-CN-6997	HNSC	TCGA	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.E305Q	DO14414	HNSC	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.P1035H	TCGA-DJ-A2QB	THCA	TCGA	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation altering degron motif	0.6583
p.P1035H	DO39421	THCA	ICGC	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation altering degron motif	0.6583
p.K310N	TCGA-DK-AA6L	BLCA	TCGA	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation substituting flanking lysine	0.3333
p.K310N	TCGA-EO-A22R	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation substituting flanking lysine	0.3333
p.K310N	DO219002	BLCA	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation substituting flanking lysine	0.3333
p.K310N	DO42713	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation substituting flanking lysine	0.3333
p.K313T	TCGA-E6-A1LX	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.K313T	DO41020	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.P319Q	TCGA-EJ-7125	PRAD	TCGA	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.P319Q	DO36326	PRAD	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.R510H	TCGA-FP-A4BE	STAD	TCGA	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.2778
p.R510H	TCGA-HU-A4GN	STAD	TCGA	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.2778
p.R510H	DO48016	STAD	ICGC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.2778
p.R510H	DO47833	STAD	ICGC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.2778
p.P225L	TCGA-FR-A726	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7582
p.P225L	DO48665	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7582
p.R513Q	DO233089	GACA	ICGC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.1944
p.P1183T	DO229028	LICA	ICGC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.0833
p.S231R	DO229037	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2778
p.P314Q	DO229054	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7035
p.E1040D	DO231183	LUSC	ICGC	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.25
p.V1173M	DO36556	READ	ICGC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation altering degron motif	0.6097
p.D312Y	DO229248	THCA	ICGC	PRSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R510C	DO41199	UCEC	ICGC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.2778
p.R502H	SIDM02049	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.2222
p.P219L	SIDM00620	Glioblastoma	GDSC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1667
p.P219L	ACH-002226	Brain Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1667
p.P219L	D-336MG	central nervous system	COSMIC	PKSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1667
p.A1022V	SIDM00789	Colorectal Carcinoma	GDSC	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.0833
p.A1022V	ACH-000997	Colon/Colorectal Cancer	CCLE	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.0833
p.A1022V	HCT-15	large intestine	COSMIC	PRTPPIT	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.0833
p.R1181H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.1389
p.R499L	SIDM01078	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.1389
p.R499L	ACH-000790	Lung Cancer	CCLE	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.1389
p.R499L	SHP-77	lung	COSMIC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.1389
p.H516R	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.1111
p.H516R	ACH-000733	Lung Cancer	CCLE	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.1111
p.H516R	NCI-H1838	lung	COSMIC	DYR	CBL_MET	506:508	Mutation rewiring degron network	0.1111
p.H1172D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation altering degron motif	0.6577
p.H1172D	ACH-000893	Lung Cancer	CCLE	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation altering degron motif	0.6577
p.H1172D	NCI-H1651	lung	COSMIC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation altering degron motif	0.6577
p.E1166Q	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.2778
p.E1166Q	ACH-000945	Lung Cancer	CCLE	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.2778
p.E1166Q	NCI-H650	lung	COSMIC	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.2778
p.R1158T	ACH-001955	Bone Cancer	CCLE	VETPHVT	DEG_SCF_FBW7_1	1168:1174	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H13

UniProt ID: Q5T200

Entrez ID: 23091

Protein name: Zinc finger CCCH domain-containing protein 13

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H13 in