DegronMD

Uniprot ID: Q5T200

Source protein: Zinc finger CCCH domain-containing protein 13

Source gene: ZC3H13

Class: DEG_SCF_FBW7_1

Location: 1031:1037

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 108.9

COIL: 0.9601

CONS_SCORE: 0.5618

DSS_SCORE: 0.7007

HELIX: 0.021

FCONS_SCORE: 1.5137

RIG_SCORE: 0.6117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1035S	TCGA-24-1564	OV	TCGA	PRTPPIT	DEG_SCF_FBW7_1	0.5641
p.P1035S	DO28022	OV	ICGC	PRTPPIT	DEG_SCF_FBW7_1	0.5641
p.P1035H	TCGA-DJ-A2QB	THCA	TCGA	PRTPPIT	DEG_SCF_FBW7_1	0.6583
p.P1035H	DO39421	THCA	ICGC	PRTPPIT	DEG_SCF_FBW7_1	0.6583
p.E1040D	DO231183	LUSC	ICGC	PRTPPIT	DEG_SCF_FBW7_1	0.25
p.A1022V	SIDM00789	Colorectal Carcinoma	GDSC	PRTPPIT	DEG_SCF_FBW7_1	0.0833
p.A1022V	ACH-000997	Colon/Colorectal Cancer	CCLE	PRTPPIT	DEG_SCF_FBW7_1	0.0833
p.A1022V	HCT-15	large_intestine	COSMIC	PRTPPIT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SCF_FBW7_1	1031:1037	PRTPPIT	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons