DegronMD

Uniprot ID: Q5T200

Source protein: Zinc finger CCCH domain-containing protein 13

Source gene: ZC3H13

Class: DEG_SPOP_SBC_1

Location: 314:318

E3 ligase: SPOP

DEGRON score: 0.9761

ASA_SCORE: 104.22

COIL: 0.9404

CONS_SCORE: 0.4623

DSS_SCORE: 0.8926

HELIX: 0.0306

FCONS_SCORE: 0.8947

RIG_SCORE: 0.5083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I327V	TCGA-33-4566	LUSC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.0833
p.I327V	DO26790	LUSC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.S325F	TCGA-B5-A11E	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.5833
p.S325F	DO41644	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.5833
p.E305Q	TCGA-CN-6997	HNSC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.0833
p.E305Q	DO14414	HNSC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.K310N	TCGA-DK-AA6L	BLCA	TCGA	PRSTS	DEG_SPOP_SBC_1	0.3333
p.K310N	TCGA-EO-A22R	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.3333
p.K310N	DO219002	BLCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3333
p.K310N	DO42713	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3333
p.K313T	TCGA-E6-A1LX	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.3056
p.K313T	DO41020	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P319Q	TCGA-EJ-7125	PRAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P319Q	DO36326	PRAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P314Q	DO229054	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7035
p.D312Y	DO229248	THCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons