DegronMD

Uniprot ID: Q5BKX6

Source protein: Solute carrier family 45 member 4

Source gene: SLC45A4

Class: DEG_SPOP_SBC_1

Location: 344:348

E3 ligase: SPOP

DEGRON score: 0.9894

ASA_SCORE: 72.6

COIL: 0.6816

CONS_SCORE: 0.2213

DSS_SCORE: 0.5127

HELIX: 0.2908

FCONS_SCORE: 1.013

RIG_SCORE: 0.6648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y347F	TCGA-22-5482	LUSC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.7528
p.T352M	TCGA-AA-A022	COAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.2222
p.G337D	TCGA-ER-A19N	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1389
p.R358C	DO233288	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0556
p.D337E	DO228971	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.A338T	DO46657	PAAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.H336Y	DO37429	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.F335V	DO43186	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.P344L	SIDM01113	Other Sarcomas	GDSC	PRSTS	DEG_SPOP_SBC_1	0.7582
p.P344L	SK-UT-1	soft_tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.7582
p.R345H	SIDM00217	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.7133
p.R345H	SNU-1040	large_intestine	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.7133
p.L356P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.L356P	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.R358H	NCI-H1155	lung	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.0556
p.T340P	NCI-H2052	pleura	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons