DegronMD

Uniprot ID: Q9P2F8

Source protein: Signal-induced proliferation-associated 1-like protein 2

Source gene: SIPA1L2

Class: DEG_SPOP_SBC_1

Location: 1104:1108

E3 ligase: SPOP

DEGRON score: 0.6375

ASA_SCORE: 87.78

COIL: 0.8752

CONS_SCORE: 0.4387

DSS_SCORE: 0.6971

HELIX: 0.0594

FCONS_SCORE: 1.1082

RIG_SCORE: 0.677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1105L	TCGA-97-A4LX	LUAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.7316
p.R1105L	DO218934	LUAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7316
p.D1115G	TCGA-BR-8591	STAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115G	DO47973	STAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.A1101T	TCGA-CG-4442	STAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.25
p.A1101T	DO38380	STAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.25
p.D1115N	TCGA-CK-6746	COAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115N	TCGA-L3-A524	LUSC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115N	DO7938	COAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115N	DO45476	LUSC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115N	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115N	ACH-000637	Esophageal Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115N	ACH-001277	Sarcoma	CCLE	PRSTS	DEG_SPOP_SBC_1	0.1389
p.D1115N	KYSE-520	oesophagus	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.R1118S	DO233211	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0556
p.L1113M	DO228971	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1944
p.P1114T	DO228985	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.Q1098H	DO50894	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.A1099G	DO231663	LINC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1944
p.Q1098R	SIDM00216	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.Q1098R	ACH-000989	Colon/Colorectal Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.1667
p.Q1098R	SNU-175	large_intestine	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.R1118I	SIDM00216	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.0556
p.R1118I	SNU-175	large_intestine	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.0556
p.S1108F	ACH-002080	Neuroblastoma	CCLE	PRSTS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons