DegronMD

Uniprot ID: Q70EL4

Source protein: Ubiquitin carboxyl-terminal hydrolase 43

Source gene: USP43

Class: DEG_SPOP_SBC_1

Location: 842:846

E3 ligase: SPOP

DEGRON score: 0.9784

ASA_SCORE: 92.26

COIL: 0.8786

CONS_SCORE: 0.2914

DSS_SCORE: 0.4272

HELIX: 0.088

FCONS_SCORE: 0.9976

RIG_SCORE: 0.6567

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V850A	TCGA-A5-A0G2	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.2222
p.V850A	DO41235	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2222
p.T854A	TCGA-AP-A1DV	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1111
p.T854A	DO43186	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.R840Q	TCGA-AX-A05Z	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.2778
p.R840Q	DO40884	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2778
p.S851L	TCGA-EB-A3XD	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1944
p.S851L	DO228138	PBCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1944
p.S851L	DO37871	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1944
p.T854M	DO233709	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.L836F	DO228952	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.LV832LM	DO222363	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	0
p.P842L	DO222880	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7582
p.Q847H	DO50690	ORCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R841I	SIDM01611	Endometrial Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R841I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons