DegronMD

Uniprot ID: P57054

Source protein: Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Source gene: PIGP

Class: DEG_SPOP_SBC_1

Location: 3:7

E3 ligase: SPOP

DEGRON score: 0.6647

ASA_SCORE: 94.36

COIL: 0.9164

CONS_SCORE: 0.4811

DSS_SCORE: 0.4213

HELIX: 0.0666

FCONS_SCORE: 1.0035

RIG_SCORE: 0.7868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T6I	TCGA-CL-5917	READ	TCGA	PRSTS	DEG_SPOP_SBC_1	0.8189
p.T6I	DO36560	READ	ICGC	PRSTS	DEG_SPOP_SBC_1	0.8189
p.T6P	TCGA-WB-A815	PCPG	TCGA	PRSTS	DEG_SPOP_SBC_1	0.8142
p.A9T	DO229010	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7222
p.A9T	DO229013	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7222
p.A9T	DO229016	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7222
p.A9T	DO229003	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7222
p.A9T	DO229005	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7222
p.L14F	DO11854	GBM	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.S5R	DO229038	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7427
p.P10T	DO229006	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.25
p.P6T	DO229008	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7031
p.N4H	DO52412	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7423
p.R12T	ACH-000799	Skin Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.1944
p.I10F	SK-MEL-24	skin	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons