DegronMD - Q5BKX6(SLC45A4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y347F	TCGA-22-5482	LUSC	TCGA	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7528
p.Y347F	TCGA-22-5482	LUSC	TCGA	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7528
p.R418L	TCGA-55-8207	LUAD	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.D406N	TCGA-61-1995	OV	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.3056
p.H417Q	TCGA-61-2087	OV	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1667
p.H417Q	TCGA-92-8065	LUSC	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1667
p.R402C	TCGA-A5-A1OF	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.T352M	TCGA-AA-A022	COAD	TCGA	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.1944
p.T352M	TCGA-AA-A022	COAD	TCGA	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.P333S	TCGA-B5-A3FC	UCEC	TCGA	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.1111
p.R415Q	TCGA-BK-A13B	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2222
p.L397P	TCGA-BR-8382	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.0556
p.M410T	TCGA-CD-A4MJ	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation altering degron motif	0.7423
p.R402H	TCGA-D5-6898	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.V476M	TCGA-EC-A24G	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation altering degron motif	0.7208
p.G337D	TCGA-ER-A19N	SKCM	TCGA	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.G337D	TCGA-ER-A19N	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1389
p.I398V	TCGA-F7-A624	HNSC	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.5278
p.Q411P	TCGA-IB-7651	PAAD	TCGA	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation altering degron motif	0.7035
p.R415W	DO10582	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2222
p.T403M	DO10647	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2222
p.R469W	DO10324	COAD	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1389
p.E487G	DO222877	COCA	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1389
p.E331K	DO228631	GACA	ICGC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.0556
p.E331K	DO233652	GACA	ICGC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.0556
p.R358C	DO233288	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.A418V	DO233701	GACA	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.A418V	SIDM00060	Ovarian Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1389
p.H468N	DO228948	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1111
p.D337E	DO228971	LICA	ICGC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.D337E	DO228971	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1389
p.T408K	DO228985	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation altering degron motif	0.6195
p.P405T	DO229015	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2778
p.H468Q	DO229029	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1111
p.H468Q	DO27074	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1111
p.H468Q	DO32039	OV	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1111
p.E487D	DO22932	LIHC	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1389
p.T399N	DO231902	LINC	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1111
p.R469L	DO45351	LUAD	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1389
p.S406L	DO224610	LUSC	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.3056
p.Y398F	DO26457	LUSC	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation blocking phosphorylation signal	0.5278
p.R420C	DO220886	MELA	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.0833
p.A338T	DO46657	PAAD	ICGC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.25
p.A338T	DO46657	PAAD	ICGC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1667
p.R420L	DO36801	READ	ICGC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.0833
p.H336Y	DO37429	SKCM	ICGC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.1944
p.H336Y	DO37429	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.T477I	DO37406	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation altering degron motif	0.5966
p.S485I	DO229229	THCA	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1944
p.R466Q	DO40825	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.0556
p.F335V	DO43186	UCEC	ICGC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.1667
p.F335V	DO43186	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.A342T	SIDM01943	Colorectal Carcinoma	GDSC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.6028
p.T343I	SIDM00313	Hodgkin's Lymphoma	GDSC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7078
p.T343I	L-1236	haematopoietic and lymphoid tissue	COSMIC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7078
p.R413W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2778
p.R413W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2778
p.P344L	SIDM01113	Other Sarcomas	GDSC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7582
p.P344L	SIDM01113	Other Sarcomas	GDSC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7582
p.P344L	SK-UT-1	soft tissue	COSMIC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7582
p.P344L	SK-UT-1	soft tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7582
p.R466W	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.0556
p.R466W	SIDM01228	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.0556
p.R345H	SIDM00217	Colorectal Carcinoma	GDSC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7133
p.R345H	SIDM00217	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7133
p.R345H	SNU-1040	large intestine	COSMIC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7133
p.R345H	SNU-1040	large intestine	COSMIC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7133
p.L356P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.0833
p.L356P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.L356P	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.0833
p.L356P	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.A343T	ACH-000427	Gastric Cancer	CCLE	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7139
p.A343T	NCI-N87	stomach	COSMIC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.7139
p.A343V	ACH-000830	Lung Cancer	CCLE	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.6936
p.A343V	NCI-H1436	lung	COSMIC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation altering degron motif	0.6936
p.T467I	ACH-001061	Colon/Colorectal Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.0833
p.D409N	ACH-001554	Eye Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	407:411	Mutation altering degron motif	0.6932
p.R358H	NCI-H1155	lung	COSMIC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.T340P	NCI-H2052	pleura	COSMIC	PATPRST	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.3056
p.T340P	NCI-H2052	pleura	COSMIC	PRSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC45A4

UniProt ID: Q5BKX6

Entrez ID: 57210

Protein name: Solute carrier family 45 member 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC45A4 in