DegronMD

Uniprot ID: Q5BKX6

Source protein: Solute carrier family 45 member 4

Source gene: SLC45A4

Class: DEG_SCF_FBW7_1

Location: 341:347

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 74.4

COIL: 0.8311

CONS_SCORE: 0.2199

DSS_SCORE: 0.4925

HELIX: 0.1451

FCONS_SCORE: 0.9959

RIG_SCORE: 0.6618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y347F	TCGA-22-5482	LUSC	TCGA	PATPRST	DEG_SCF_FBW7_1	0.7528
p.T352M	TCGA-AA-A022	COAD	TCGA	PATPRST	DEG_SCF_FBW7_1	0.1944
p.P333S	TCGA-B5-A3FC	UCEC	TCGA	PATPRST	DEG_SCF_FBW7_1	0.1111
p.G337D	TCGA-ER-A19N	SKCM	TCGA	PATPRST	DEG_SCF_FBW7_1	0.2222
p.E331K	DO228631	GACA	ICGC	PATPRST	DEG_SCF_FBW7_1	0.0556
p.E331K	DO233652	GACA	ICGC	PATPRST	DEG_SCF_FBW7_1	0.0556
p.D337E	DO228971	LICA	ICGC	PATPRST	DEG_SCF_FBW7_1	0.2222
p.A338T	DO46657	PAAD	ICGC	PATPRST	DEG_SCF_FBW7_1	0.25
p.H336Y	DO37429	SKCM	ICGC	PATPRST	DEG_SCF_FBW7_1	0.1944
p.F335V	DO43186	UCEC	ICGC	PATPRST	DEG_SCF_FBW7_1	0.1667
p.A342T	SIDM01943	Colorectal Carcinoma	GDSC	PATPRST	DEG_SCF_FBW7_1	0.6028
p.T343I	SIDM00313	Hodgkin's Lymphoma	GDSC	PATPRST	DEG_SCF_FBW7_1	0.7078
p.T343I	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRST	DEG_SCF_FBW7_1	0.7078
p.P344L	SIDM01113	Other Sarcomas	GDSC	PATPRST	DEG_SCF_FBW7_1	0.7582
p.P344L	SK-UT-1	soft_tissue	COSMIC	PATPRST	DEG_SCF_FBW7_1	0.7582
p.R345H	SIDM00217	Colorectal Carcinoma	GDSC	PATPRST	DEG_SCF_FBW7_1	0.7133
p.R345H	SNU-1040	large_intestine	COSMIC	PATPRST	DEG_SCF_FBW7_1	0.7133
p.L356P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PATPRST	DEG_SCF_FBW7_1	0.0833
p.L356P	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPRST	DEG_SCF_FBW7_1	0.0833
p.A343T	ACH-000427	Gastric Cancer	CCLE	PATPRST	DEG_SCF_FBW7_1	0.7139
p.A343T	NCI-N87	stomach	COSMIC	PATPRST	DEG_SCF_FBW7_1	0.7139
p.A343V	ACH-000830	Lung Cancer	CCLE	PATPRST	DEG_SCF_FBW7_1	0.6936
p.A343V	NCI-H1436	lung	COSMIC	PATPRST	DEG_SCF_FBW7_1	0.6936
p.T340P	NCI-H2052	pleura	COSMIC	PATPRST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5BKX6	Solute carrier family 45 member 4	DEG_SCF_FBW7_1	341:347	PATPRST	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons