DegronMD - P13646(KRT13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T435M	TCGA-AB-2826	LAML	TCGA	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.7423
p.T435M	DO21833	LAML	ICGC	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.7423
p.R451H	TCGA-AX-A1CE	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1667
p.R451H	DO234401	ESAD	ICGC	VTTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1667
p.R451H	DO42280	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1667
p.G418D	TCGA-DM-A0XD	COAD	TCGA	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0556
p.G418D	DO10228	COAD	ICGC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0556
p.S440F	TCGA-IG-A5S3	ESCA	TCGA	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1111
p.S440F	TCGA-IG-A5S3	ESCA	TCGA	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.25
p.S440F	TCGA-IG-A5S3	ESCA	TCGA	VTTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.T452N	DO229031	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	441:445	Mutation blocking phosphorylation signal	0.5833
p.A423T	DO229036	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1944
p.A423T	DO229036	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.0556
p.A439D	DO229045	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1389
p.A439D	DO229045	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.2778
p.A439D	DO229045	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.2778
p.P420L	DO222868	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1111
p.S425N	DO232224	PBCA	ICGC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation blocking phosphorylation signal	0.6944
p.S425N	DO232224	PBCA	ICGC	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation blocking phosphorylation signal	0.5556
p.R450C	SIDM01958	Esophageal Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1944
p.V426I	SIDM01261	Breast Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.2778
p.V426I	SIDM01261	Breast Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1389
p.V426I	SIDM00868	Non-Cancerous	GDSC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.2778
p.V426I	SIDM00868	Non-Cancerous	GDSC	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1389
p.V426I	SIDM01049	Non-Cancerous	GDSC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.2778
p.V426I	SIDM01049	Non-Cancerous	GDSC	VTTTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1389
p.S430N	SIDM00183	Small Cell Lung Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.7069
p.P420S	SIDM00930	Osteosarcoma	GDSC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1111
p.P420S	ACH-001715	Bone Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1111
p.P420S	CAL-72	bone	COSMIC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1111
p.R429C	SIDM01629	Melanoma	GDSC	PRSTS	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.719

Kaplan plot for KRT13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT13

UniProt ID: P13646

Entrez ID: 3860

Protein name: Keratin, type I cytoskeletal 13 (Cytokeratin-13) (CK-13) (Keratin-13) (K13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT13 in