DegronMD

Uniprot ID: P13646

Source protein: Keratin, type I cytoskeletal 13

Source gene: KRT13

Class: DEG_SPOP_SBC_1

Location: 428:432

E3 ligase: SPOP

DEGRON score: 0.917

ASA_SCORE: 103.9

COIL: 0.8832

CONS_SCORE: 0.8431

DSS_SCORE: 0.5483

HELIX: 0.0196

FCONS_SCORE: 1.005

RIG_SCORE: 0.6095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G418D	TCGA-DM-A0XD	COAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.0556
p.G418D	DO10228	COAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0556
p.S440F	TCGA-IG-A5S3	ESCA	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1111
p.A423T	DO229036	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1944
p.A439D	DO229045	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.P420L	DO222868	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.S425N	DO232224	PBCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.6944
p.V426I	SIDM01261	Breast Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.2778
p.V426I	SIDM00868	Non-Cancerous	GDSC	PRSTS	DEG_SPOP_SBC_1	0.2778
p.V426I	SIDM01049	Non-Cancerous	GDSC	PRSTS	DEG_SPOP_SBC_1	0.2778
p.S430N	SIDM00183	Small Cell Lung Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.7069
p.P420S	SIDM00930	Osteosarcoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.P420S	ACH-001715	Bone Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.1111
p.P420S	CAL-72	bone	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.R429C	SIDM01629	Melanoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons