DegronMD - Q9H792(PEAK1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A763S	TCGA-06-5416	GBM	TCGA	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.A763S	DO10880	GBM	ICGC	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.S854T	TCGA-12-0670	GBM	TCGA	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation altering degron motif	0.7116
p.S854T	DO12226	GBM	ICGC	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation altering degron motif	0.7116
p.R874C	TCGA-74-6581	GBM	TCGA	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.719
p.R874C	DO11531	GBM	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.719
p.K544N	TCGA-A5-A2K5	UCEC	TCGA	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation substituting flanking lysine	0.2778
p.K544N	DO41379	UCEC	ICGC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation substituting flanking lysine	0.2778
p.K857E	TCGA-AJ-A5DW	UCEC	TCGA	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation rewiring degron network	0.3056
p.K857E	DO50075	UCEC	ICGC	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation rewiring degron network	0.3056
p.T615A	TCGA-BR-A4J8	STAD	TCGA	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation blocking phosphorylation signal	0.7222
p.T615A	DO38527	STAD	ICGC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation blocking phosphorylation signal	0.7222
p.R760K	TCGA-CV-7427	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2778
p.R760K	DO14286	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2778
p.Q1444H	TCGA-DK-AA71	BLCA	TCGA	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation altering degron motif	0.647
p.Q1444H	DO219010	BLCA	ICGC	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation altering degron motif	0.647
p.P879L	TCGA-EE-A20F	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2778
p.P879L	DO37961	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.2778
p.E750K	TCGA-FD-A3B6	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2222
p.E750K	DO458	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2222
p.S878F	TCGA-FD-A5BX	BLCA	TCGA	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation blocking phosphorylation signal	0.75
p.S878F	DO44079	BLCA	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation blocking phosphorylation signal	0.75
p.S758I	TCGA-FI-A2F4	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7341
p.S758I	DO43434	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7341
p.L885I	TCGA-HU-A4GQ	STAD	TCGA	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1111
p.L885I	DO47767	STAD	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1111
p.S1443F	TCGA-IB-7651	PAAD	TCGA	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation rewiring degron network	0.3056
p.S1443F	DO46657	PAAD	ICGC	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation rewiring degron network	0.3056
p.E1439K	TCGA-VS-A9U7	CESC	TCGA	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation rewiring degron network	0.1944
p.E1439K	DO219729	CESC	ICGC	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation rewiring degron network	0.1944
p.E533K	DO224768	BRCA	ICGC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.3056
p.H611Y	DO234344	ESAD	ICGC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation altering degron motif	0.6118
p.S511L	DO222639	ESCA	ICGC	PVTSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.7667
p.P872L	DO233888	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.3056
p.P872L	SIDM01770	Gastric Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.3056
p.A1440V	DO233900	GACA	ICGC	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation rewiring degron network	0.2222
p.S861R	DO228952	LICA	ICGC	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation blocking phosphorylation signal	0.6389
p.Q543K	DO228985	LICA	ICGC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1944
p.L886F	DO229018	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.0833
p.A1440E	DO229037	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation rewiring degron network	0.2222
p.T539N	DO229037	LICA	ICGC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation blocking phosphorylation signal	0.75
p.Q1448K	DO229045	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	1444:1448	Mutation altering degron motif	0.5833
p.P862T	DO229061	LICA	ICGC	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation rewiring degron network	0.1667
p.P866T	DO229009	LICA	ICGC	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation rewiring degron network	0.0556
p.P866T	DO229009	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1389
p.S526Y	DO23539	LIRI	ICGC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1111
p.I608V	DO222824	MELA	ICGC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation altering degron motif	0.5965
p.R874H	DO48902	PBCA	ICGC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation altering degron motif	0.7133
p.W535R	DO232761	PBCA	ICGC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7523
p.P867Q	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.P867Q	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.P867Q	ACH-000681	Lung Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.P867Q	A549	lung	COSMIC	PRSTS	DEG_SPOP_SBC_1	873:877	Mutation rewiring degron network	0.1667
p.H611Q	SIDM00181	Bladder Carcinoma	GDSC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation altering degron motif	0.7582
p.H611Q	ACH-002266	Bladder Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation altering degron motif	0.7582
p.H611Q	LB831-BLC	urinary tract	COSMIC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation altering degron motif	0.7582
p.N599S	SIDM00537	Colorectal Carcinoma	GDSC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation rewiring degron network	0.0833
p.N599S	ACH-000982	Colon/Colorectal Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation rewiring degron network	0.0833
p.N599S	ACH-001345	Colon/Colorectal Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation rewiring degron network	0.0833
p.N599S	GP5d	large intestine	COSMIC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation rewiring degron network	0.0833
p.M603L	SIDM00999	Bladder Carcinoma	GDSC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation rewiring degron network	0.1944
p.M603L	ACH-000973	Bladder Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation rewiring degron network	0.1944
p.M603L	639-V	urinary tract	COSMIC	IIIHDE	LIG_APCC_ABBA_1	608:613	Mutation rewiring degron network	0.1944
p.P855S	SIDM00528	Breast Carcinoma	GDSC	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation altering degron motif	0.5641
p.P855S	ACH-000934	Breast Cancer	CCLE	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation altering degron motif	0.5641
p.P855S	MDA-MB-361	breast	COSMIC	PVTPSPS	DEG_SCF_FBW7_1	850:856	Mutation altering degron motif	0.5641
p.S538I	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7341
p.S538I	ACH-000869	Lung Cancer	CCLE	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7341
p.S538I	NCI-H1568	lung	COSMIC	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7341
p.S503P	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	508:512	Mutation blocking phosphorylation signal	0.6389
p.S503P	ACH-000912	Lung Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	508:512	Mutation blocking phosphorylation signal	0.6389
p.K525N	ACH-000774	Lung Cancer	CCLE	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation substituting flanking lysine	0.1944
p.K544T	ACH-002680	Brain Cancer	CCLE	VWTSS	DEG_SPOP_SBC_1	534:538	Mutation substituting flanking lysine	0.2778
p.N506I	SNU-C2B	large intestine	COSMIC	PVTSS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PEAK1

UniProt ID: Q9H792

Entrez ID: 79834

Protein name: Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PEAK1 in