DegronMD

Uniprot ID: Q9H792

Source protein: Inactive tyrosine-protein kinase PEAK1

Source gene: PEAK1

Class: DEG_SCF_FBW7_1

Location: 850:856

E3 ligase: FBXW7

DEGRON score: 0.9641

ASA_SCORE: 95.9857

COIL: 0.9656

CONS_SCORE: 0.2657

DSS_SCORE: 0.7184

HELIX: 0.0109

FCONS_SCORE: 0.8161

RIG_SCORE: 0.5836

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S854T	TCGA-12-0670	GBM	TCGA	PVTPSPS	DEG_SCF_FBW7_1	0.7116
p.S854T	DO12226	GBM	ICGC	PVTPSPS	DEG_SCF_FBW7_1	0.7116
p.S861R	DO228952	LICA	ICGC	PVTPSPS	DEG_SCF_FBW7_1	0.6389
p.P855S	SIDM00528	Breast Carcinoma	GDSC	PVTPSPS	DEG_SCF_FBW7_1	0.5641
p.P855S	ACH-000934	Breast Cancer	CCLE	PVTPSPS	DEG_SCF_FBW7_1	0.5641
p.P855S	MDA-MB-361	breast	COSMIC	PVTPSPS	DEG_SCF_FBW7_1	0.5641
p.K857E	TCGA-AJ-A5DW	UCEC	TCGA	PVTPSPS	DEG_SCF_FBW7_1	0.3056
p.K857E	DO50075	UCEC	ICGC	PVTPSPS	DEG_SCF_FBW7_1	0.3056
p.P862T	DO229061	LICA	ICGC	PVTPSPS	DEG_SCF_FBW7_1	0.1667
p.P866T	DO229009	LICA	ICGC	PVTPSPS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SCF_FBW7_1	850:856	PVTPSPS	FBXW7	0.9641	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons