DegronMD

Uniprot ID: Q9H792

Source protein: Inactive tyrosine-protein kinase PEAK1

Source gene: PEAK1

Class: DEG_SPOP_SBC_1

Location: 873:877

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 102

COIL: 0.9598

CONS_SCORE: 0.6095

DSS_SCORE: 0.7053

HELIX: 0.0216

FCONS_SCORE: 1.1909

RIG_SCORE: 0.5396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R874C	TCGA-74-6581	GBM	TCGA	PRSTS	DEG_SPOP_SBC_1	0.719
p.R874C	DO11531	GBM	ICGC	PRSTS	DEG_SPOP_SBC_1	0.719
p.P879L	TCGA-EE-A20F	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	0.2778
p.P879L	DO37961	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2778
p.S878F	TCGA-FD-A5BX	BLCA	TCGA	PRSTS	DEG_SPOP_SBC_1	0.75
p.S878F	DO44079	BLCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.75
p.L885I	TCGA-HU-A4GQ	STAD	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1111
p.L885I	DO47767	STAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.P872L	DO233888	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P872L	SIDM01770	Gastric Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.L886F	DO229018	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.P866T	DO229009	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1389
p.R874H	DO48902	PBCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.7133
p.P867Q	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.P867Q	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.P867Q	ACH-000681	Lung Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.1667
p.P867Q	A549	lung	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons