DegronMD

Uniprot ID: Q9BYB0

Source protein: SH3 and multiple ankyrin repeat domains protein 3

Source gene: SHANK3

Class: DEG_SPOP_SBC_1

Location: 798:802

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 67.74

COIL: 0.7854

CONS_SCORE: 0.3546

DSS_SCORE: 0.6781

HELIX: 0.0814

FCONS_SCORE: 1.057

RIG_SCORE: 0.6218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G792E	TCGA-D1-A163	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1667
p.G792E	DO41008	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.A806T	DO234230	ESAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2222
p.G792R	DO233862	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.L789F	DO229029	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.A812V	ACH-001145	Ovarian Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons