DegronMD - Q8IWB9(TEX2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y1106C	TCGA-85-8276	LUSC	TCGA	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.25
p.I1109T	TCGA-B5-A0K9	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation altering degron motif	0.7078
p.I287N	TCGA-BG-A0LX	UCEC	TCGA	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation rewiring degron network	0.2222
p.I287N	DO41919	UCEC	ICGC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation rewiring degron network	0.2222
p.S140L	TCGA-BR-8078	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S140L	DO222749	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S140L	DO38288	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S140L	ACH-002396	Bone Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S140L	Sarc9371	bone	COSMIC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.T129A	TCGA-CG-5726	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.T129A	DO38483	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.G142E	TCGA-CR-6478	HNSC	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.G142E	DO15839	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.I172F	TCGA-DD-AACP	LIHC	TCGA	ASTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1944
p.I172F	DO52210	LIHC	ICGC	ASTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1944
p.E311D	TCGA-DD-AACT	LIHC	TCGA	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.E311D	DO219563	LIHC	ICGC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.P148H	TCGA-DK-A6B5	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1111
p.P148H	DO48551	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1111
p.N1101T	TCGA-EB-A299	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.1111
p.P1116T	TCGA-EE-A2MQ	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.25
p.P1116T	ACH-000261	Lung Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.25
p.P1116T	ACH-002122	Lung Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.25
p.S135F	TCGA-GN-A26C	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S135F	DO37782	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.A320S	TCGA-IG-A3Y9	ESCA	TCGA	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7588
p.K279R	TCGA-IN-A6RL	STAD	TCGA	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation altering degron motif	0.6126
p.K279R	DO51738	STAD	ICGC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation altering degron motif	0.6126
p.L334F	TCGA-JW-A5VL	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.L334F	DO49976	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.S324G	TCGA-LG-A9QC	LIHC	TCGA	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.6993
p.S324G	DO49701	LIHC	ICGC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.6993
p.S168C	TCGA-QK-A6IG	HNSC	TCGA	ASTST	DEG_SPOP_SBC_1	177:181	Mutation blocking phosphorylation signal	0.5278
p.S168C	DO50002	HNSC	ICGC	ASTST	DEG_SPOP_SBC_1	177:181	Mutation blocking phosphorylation signal	0.5278
p.P136L	TCGA-S9-A7QY	LGG	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7582
p.P136L	DO50215	LGG	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7582
p.S141L	TCGA-VQ-A8P2	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S141L	DO51761	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S141L	SIDM00118	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S141L	SIDM01594	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S141L	ACH-000083	Non-Cancerous	CCLE	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S141L	ACH-001081	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S141L	HCC2998	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S138L	TCGA-W3-AA1V	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.S138L	DO51276	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7667
p.L334V	TCGA-Z7-A8R6	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.L334V	DO51231	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.Y1099S	DO48421	BLCA	ICGC	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.0556
p.V150M	DO223052	ESCA	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.R1110L	DO228252	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation altering degron motif	0.7316
p.P1120T	DO229045	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.1389
p.Y1099C	DO26436	LUSC	ICGC	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.0556
p.I172T	DO220898	MELA	ICGC	ASTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1944
p.S176R	DO222527	MELA	ICGC	ASTST	DEG_SPOP_SBC_1	177:181	Mutation blocking phosphorylation signal	0.75
p.A325T	DO232761	PBCA	ICGC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.S141P	DO36556	READ	ICGC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.P1109T	DO37810	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation altering degron motif	0.7031
p.I1102T	DO42097	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.1389
p.R293H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0556
p.R293H	ACH-000795	Leukemia	CCLE	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0556
p.R293H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0556
p.S323A	SIDM00845	Burkitt's Lymphoma	GDSC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.87
p.S323A	SIDM00461	Acute Myeloid Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.87
p.E312D	SIDM00336	Melanoma	GDSC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1111
p.E312D	SIDM00506	Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1111
p.E312D	SIDM00667	Other Sarcomas	GDSC	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1111
p.R275H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation altering degron motif	0.7133
p.R275H	ACH-000922	Leukemia	CCLE	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation altering degron motif	0.7133
p.R275H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation altering degron motif	0.7133
p.F278L	SIDM00282	Colorectal Carcinoma	GDSC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation altering degron motif	0.587
p.P131S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.P131S	ACH-001127	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.P131S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.S147T	SIDM00220	Ovarian Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.S147T	ACH-000962	Ovarian Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.S147T	ACH-001145	Ovarian Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.S147T	OC-314	ovary	COSMIC	PGSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.A263S	SIDM00169	Head and Neck Carcinoma	GDSC	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0833
p.A263S	ACH-000692	Head and Neck Cancer	CCLE	SDTRSFFKVPEM	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0833
p.G314S	ACH-000071	Non-Cancerous	CCLE	ALSSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.R1117H	ACH-001131	Skin Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	1109:1113	Mutation substituting flanking lysine	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TEX2

UniProt ID: Q8IWB9

Entrez ID: 55852

Protein name: Testis-expressed protein 2 (Transmembrane protein 96)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TEX2 in