DegronMD

Uniprot ID: Q8IWB9

Source protein: Testis-expressed protein 2

Source gene: TEX2

Class: DEG_COP1_1

Location: 272:283

E3 ligase: COP1

DEGRON score: 0.7895

ASA_SCORE: 86.325

COIL: 0.6642

CONS_SCORE: 0.3121

DSS_SCORE: 0.5379

HELIX: 0.2573

FCONS_SCORE: 0.8683

RIG_SCORE: 0.7263

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I287N	TCGA-BG-A0LX	UCEC	TCGA	SDTRSFFKVPEM	DEG_COP1_1	0.2222
p.I287N	DO41919	UCEC	ICGC	SDTRSFFKVPEM	DEG_COP1_1	0.2222
p.K279R	TCGA-IN-A6RL	STAD	TCGA	SDTRSFFKVPEM	DEG_COP1_1	0.6126
p.K279R	DO51738	STAD	ICGC	SDTRSFFKVPEM	DEG_COP1_1	0.6126
p.R293H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	SDTRSFFKVPEM	DEG_COP1_1	0.0556
p.R293H	ACH-000795	Leukemia	CCLE	SDTRSFFKVPEM	DEG_COP1_1	0.0556
p.R293H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	SDTRSFFKVPEM	DEG_COP1_1	0.0556
p.R275H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	SDTRSFFKVPEM	DEG_COP1_1	0.7133
p.R275H	ACH-000922	Leukemia	CCLE	SDTRSFFKVPEM	DEG_COP1_1	0.7133
p.R275H	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	SDTRSFFKVPEM	DEG_COP1_1	0.7133
p.F278L	SIDM00282	Colorectal Carcinoma	GDSC	SDTRSFFKVPEM	DEG_COP1_1	0.587
p.A263S	SIDM00169	Head and Neck Carcinoma	GDSC	SDTRSFFKVPEM	DEG_COP1_1	0.0833
p.A263S	ACH-000692	Head and Neck Cancer	CCLE	SDTRSFFKVPEM	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWB9	Testis-expressed protein 2	DEG_COP1_1	272:283	SDTRSFFKVPEM	COP1	0.7895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons