DegronMD - Q9P2F8(SIPA1L2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1258F	TCGA-43-5668	LUSC	TCGA	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.1667
p.I1258F	DO26608	LUSC	ICGC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.1667
p.D1264N	TCGA-55-A4DF	LUAD	TCGA	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation altering degron motif	0.6932
p.D1264N	TCGA-LN-A4A2	ESCA	TCGA	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation altering degron motif	0.6932
p.D1264N	DO227709	COCA	ICGC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation altering degron motif	0.6932
p.D1264N	DO45318	LUAD	ICGC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation altering degron motif	0.6932
p.M1273V	TCGA-66-2755	LUSC	TCGA	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.2222
p.M1273V	DO27365	LUSC	ICGC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.2222
p.R1079T	TCGA-85-8277	LUSC	TCGA	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1389
p.R1079T	DO26719	LUSC	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1389
p.R1105L	TCGA-97-A4LX	LUAD	TCGA	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.7316
p.R1105L	DO218934	LUAD	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.7316
p.R1068W	TCGA-A5-A0G2	UCEC	TCGA	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.7523
p.R1068W	DO229213	THCA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.7523
p.R1068W	DO41235	UCEC	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.7523
p.I424S	TCGA-AA-3815	COAD	TCGA	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.0833
p.I424S	TCGA-AA-3815	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1944
p.I424S	DO9924	COAD	ICGC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.0833
p.I424S	DO9924	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1944
p.T1065A	TCGA-B5-A3FA	UCEC	TCGA	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.825
p.T1065A	DO52402	UCEC	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.825
p.T1065M	TCGA-BR-6457	STAD	TCGA	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.8534
p.T1065M	DO38759	STAD	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.8534
p.D1115G	TCGA-BR-8591	STAD	TCGA	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115G	DO47973	STAD	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.A1101T	TCGA-CG-4442	STAD	TCGA	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.25
p.A1101T	DO38380	STAD	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.25
p.D1115N	TCGA-CK-6746	COAD	TCGA	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115N	TCGA-L3-A524	LUSC	TCGA	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115N	DO7938	COAD	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115N	DO45476	LUSC	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115N	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115N	ACH-000637	Esophageal Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115N	ACH-001277	Sarcoma	CCLE	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D1115N	KYSE-520	oesophagus	COSMIC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.S431L	TCGA-D1-A16J	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7667
p.S431L	DO43033	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.7667
p.D1268N	TCGA-D1-A17Q	UCEC	TCGA	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation altering degron motif	0.5821
p.D1268N	DO41903	UCEC	ICGC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation altering degron motif	0.5821
p.P1072L	TCGA-D3-A3ML	SKCM	TCGA	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.6471
p.P1072L	DO47413	SKCM	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.6471
p.R1079G	TCGA-D3-A3MO	SKCM	TCGA	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1389
p.R1079G	DO37427	SKCM	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1389
p.N430K	TCGA-D6-6516	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.5806
p.N430K	DO15623	HNSC	ICGC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.5806
p.N430T	TCGA-D6-6516	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.5944
p.N430T	DO15623	HNSC	ICGC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation altering degron motif	0.5944
p.R1068Q	TCGA-EY-A215	UCEC	TCGA	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.6218
p.R1068Q	DO224757	COCA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.6218
p.R1068Q	DO42665	UCEC	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.6218
p.E419K	TCGA-HU-A4GT	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.0556
p.E419K	DO48020	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.0556
p.S436Y	DO222765	COCA	ICGC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation altering degron motif	0.712
p.P1082L	DO234403	ESAD	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.0556
p.R1118S	DO233211	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.0556
p.E438K	DO233663	GACA	ICGC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation altering degron motif	0.7022
p.D1268H	DO229493	LAML	ICGC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation altering degron motif	0.6577
p.L1113M	DO228971	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1944
p.P1114T	DO228985	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1667
p.S447R	DO229036	LICA	ICGC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.0833
p.Q1098H	DO50894	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1667
p.P1070L	DO231694	LINC	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.7582
p.A1099G	DO231663	LINC	ICGC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1944
p.H1067N	DO230525	LUSC	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation altering degron motif	0.6312
p.P1059L	DO220891	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1944
p.P1059L	DO222714	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1944
p.P1059L	DO222875	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1944
p.P1059S	DO220891	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1944
p.P1059F	DO220891	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1944
p.T1263S	DO35350	PACA	ICGC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.3056
p.R1062W	DO229227	THCA	ICGC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.2778
p.Q1098R	SIDM00216	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1667
p.Q1098R	ACH-000989	Colon/Colorectal Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1667
p.Q1098R	SNU-175	large intestine	COSMIC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1667
p.R1118I	SIDM00216	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.0556
p.R1118I	SNU-175	large intestine	COSMIC	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.0556
p.R423Q	SIDM00475	Ovarian Carcinoma	GDSC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.0556
p.R423Q	SIDM00475	Ovarian Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.R423Q	ACH-000091	Ovarian Cancer	CCLE	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.0556
p.R423Q	ACH-000091	Ovarian Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.R423Q	OV-56	ovary	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.0556
p.R423Q	OV-56	ovary	COSMIC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.I1258V	SIDM00663	Melanoma	GDSC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.1667
p.I1258V	ACH-000814	Skin Cancer	CCLE	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.1667
p.I1258V	Hs939-T	skin	COSMIC	DSGIDT	DEG_SCF_TRCP1_1	1264:1269	Mutation rewiring degron network	0.1667
p.L1077P	ACH-000999	Colon/Colorectal Cancer	CCLE	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1944
p.L1077P	SNU-1040	large intestine	COSMIC	TTWHRVPTP	DEG_COP1_1	1064:1072	Mutation rewiring degron network	0.1944
p.S1108F	ACH-002080	Neuroblastoma	CCLE	PRSTS	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.7982
p.I444T	NCI-H1092	lung	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.1667
p.S439L	C-4-I	cervix	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation rewiring degron network	0.3056
p.S439L	C-4-I	cervix	COSMIC	ANSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1667
p.D438V	JIMT-1	breast	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	433:438	Mutation altering degron motif	0.7785

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIPA1L2

UniProt ID: Q9P2F8

Entrez ID: 57568

Protein name: Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIPA1L2 in