DegronMD

Uniprot ID: Q9P2F8

Source protein: Signal-induced proliferation-associated 1-like protein 2

Source gene: SIPA1L2

Class: DEG_Kelch_Keap1_1

Location: 433:438

E3 ligase: KEAP1

DEGRON score: 0.79

ASA_SCORE: 72.9333

COIL: 0.8182

CONS_SCORE: 0.3632

DSS_SCORE: 0.3325

HELIX: 0.1077

FCONS_SCORE: 0.8919

RIG_SCORE: 0.6015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I424S	TCGA-AA-3815	COAD	TCGA	SFSSGE	DEG_Kelch_Keap1_1	0.0833
p.I424S	DO9924	COAD	ICGC	SFSSGE	DEG_Kelch_Keap1_1	0.0833
p.S436Y	DO222765	COCA	ICGC	SFSSGE	DEG_Kelch_Keap1_1	0.712
p.E438K	DO233663	GACA	ICGC	SFSSGE	DEG_Kelch_Keap1_1	0.7022
p.S447R	DO229036	LICA	ICGC	SFSSGE	DEG_Kelch_Keap1_1	0.0833
p.R423Q	SIDM00475	Ovarian Carcinoma	GDSC	SFSSGE	DEG_Kelch_Keap1_1	0.0556
p.R423Q	ACH-000091	Ovarian Cancer	CCLE	SFSSGE	DEG_Kelch_Keap1_1	0.0556
p.R423Q	OV-56	ovary	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	0.0556
p.I444T	NCI-H1092	lung	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	0.1667
p.S439L	C-4-I	cervix	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	0.3056
p.D438V	JIMT-1	breast	COSMIC	SFSSGE	DEG_Kelch_Keap1_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_Kelch_Keap1_1	433:438	SFSSGE	KEAP1	0.79	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons