DegronMD

Uniprot ID: Q9P2F8

Source protein: Signal-induced proliferation-associated 1-like protein 2

Source gene: SIPA1L2

Class: DEG_COP1_1

Location: 1064:1072

E3 ligase: COP1

DEGRON score: 0.9933

ASA_SCORE: 98.3778

COIL: 0.899

CONS_SCORE: 0.3956

DSS_SCORE: 0.4949

HELIX: 0.0696

FCONS_SCORE: 0.9766

RIG_SCORE: 0.76

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1079T	TCGA-85-8277	LUSC	TCGA	TTWHRVPTP	DEG_COP1_1	0.1389
p.R1079T	DO26719	LUSC	ICGC	TTWHRVPTP	DEG_COP1_1	0.1389
p.R1068W	TCGA-A5-A0G2	UCEC	TCGA	TTWHRVPTP	DEG_COP1_1	0.7523
p.R1068W	DO229213	THCA	ICGC	TTWHRVPTP	DEG_COP1_1	0.7523
p.R1068W	DO41235	UCEC	ICGC	TTWHRVPTP	DEG_COP1_1	0.7523
p.T1065A	TCGA-B5-A3FA	UCEC	TCGA	TTWHRVPTP	DEG_COP1_1	0.825
p.T1065A	DO52402	UCEC	ICGC	TTWHRVPTP	DEG_COP1_1	0.825
p.T1065M	TCGA-BR-6457	STAD	TCGA	TTWHRVPTP	DEG_COP1_1	0.8534
p.T1065M	DO38759	STAD	ICGC	TTWHRVPTP	DEG_COP1_1	0.8534
p.P1072L	TCGA-D3-A3ML	SKCM	TCGA	TTWHRVPTP	DEG_COP1_1	0.6471
p.P1072L	DO47413	SKCM	ICGC	TTWHRVPTP	DEG_COP1_1	0.6471
p.R1079G	TCGA-D3-A3MO	SKCM	TCGA	TTWHRVPTP	DEG_COP1_1	0.1389
p.R1079G	DO37427	SKCM	ICGC	TTWHRVPTP	DEG_COP1_1	0.1389
p.R1068Q	TCGA-EY-A215	UCEC	TCGA	TTWHRVPTP	DEG_COP1_1	0.6218
p.R1068Q	DO224757	COCA	ICGC	TTWHRVPTP	DEG_COP1_1	0.6218
p.R1068Q	DO42665	UCEC	ICGC	TTWHRVPTP	DEG_COP1_1	0.6218
p.P1082L	DO234403	ESAD	ICGC	TTWHRVPTP	DEG_COP1_1	0.0556
p.P1070L	DO231694	LINC	ICGC	TTWHRVPTP	DEG_COP1_1	0.7582
p.H1067N	DO230525	LUSC	ICGC	TTWHRVPTP	DEG_COP1_1	0.6312
p.P1059L	DO220891	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	0.1944
p.P1059L	DO222714	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	0.1944
p.P1059L	DO222875	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	0.1944
p.P1059S	DO220891	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	0.1944
p.P1059F	DO220891	MELA	ICGC	TTWHRVPTP	DEG_COP1_1	0.1944
p.R1062W	DO229227	THCA	ICGC	TTWHRVPTP	DEG_COP1_1	0.2778
p.L1077P	ACH-000999	Colon/Colorectal Cancer	CCLE	TTWHRVPTP	DEG_COP1_1	0.1944
p.L1077P	SNU-1040	large_intestine	COSMIC	TTWHRVPTP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_COP1_1	1064:1072	TTWHRVPTP	COP1	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons